Ibrutinib Impurity 46 CAS 330786-24-8

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.330786-24-8
Molecular FormulaC17H13N5O
Molecular Weight303.32 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Ibrutinib Impurity 46 CAS 330786-24-8 chemical structure

Description

CATO supplies Ibrutinib Impurity 46 (CAS 330786-24-8), a pharmacopoeial impurity reference standard (molecular formula C17H13N5O, MW 303.32 g/mol) used for the identification and quantification of trace impurities in APIs.

Based on its molecular formula C17H13N5O, Ibrutinib Impurity 46 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 303.32 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC17H13N5O
Molecular Weight303.32 g/mol
AppearancePale yellow to yellow crystalline powder
Purity>95%
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)14.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2025
Nitrogen Atoms5

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