6-Chloro-2-(thiophen-2-yl)quinoline-4-carboxylic acid CAS 33289-51-9
| CAS No. | 33289-51-9 |
| Molecular Formula | C14H8ClNO2S |
| Molecular Weight | 289.74 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 6-Chloro-2-(thiophen-2-yl)quinoline-4-carboxylic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
6-Chloro-2-(thiophen-2-yl)quinoline-4-carboxylic acid (CAS 33289-51-9), molecular formula C14H8ClNO2S and molecular weight 289.74 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-Chloro-2-(thiophen-2-yl)quinoline-4-carboxylic acid (C14H8ClNO2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 6-Chloro-2-(thiophen-2-yl)quinoline-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H8ClNO2S |
| Molecular Weight | 289.74 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 3-Chloro-N-(thieno[2,3-d]pyrimidin-4-yl)benzamide (CAS 1003159-68-9)
- 4-Chloro-7-(4-fluorophenyl)-2,5,6-trimethyl-7H-pyrrolo[2,3-d]pyrimidine (CAS 1031555-68-6)
- 2-Chloro-5-(pyrrolidine-1-sulfonyl)benzoic acid (CAS 151104-21-1)
- 2-(5-Chloro-6-oxo-4-thiomorpholinopyridazin-1(6H)-yl)acetic acid (CAS 1707394-29-3)
- 2-(5-Chloro-thiophen-2-yl)-quinoline-4-carboxylic acid (CAS 329222-93-7)
- 2-chloro-4-(1,1-dioxido-1,2-thiaZinan-2-yl)benzoic acid (CAS 887129-69-3)
- 3-(5-Chloro-2-methylbenzo[d]thiazol-3-ium-3-yl)propane-1-sulfonate hydrate (CAS 51981-33-0)
- 4-chloro-3-(1,1-dioxido-1,2-thiaZinan-2-yl)benzoic acid (CAS 927996-03-0)
Recommended Standards
- 5-Chlorobenzo[c]isothiazol-3-yl benzoate (CAS 63285-90-5)
- N-(benzo[d]thiazol-2-yl)-2-chloronicotinamide (CAS 85678-85-9)
- 4-Cyclopropaneamido-2-methoxybenzene-1-sulfonyl chloride (CAS 926187-74-8)
- Quinethazone (CAS 73-49-4)
- Levonorgestrel EP Impurity I (CAS 20402-62-4)
- 1-(3-Chloro-4-fluorophenyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1039901-95-5)
- Nivalenol (CAS 23282-20-4)
- Methyl 6-{[2-(4-methoxybenzenesulfonamido)phenyl]sulfanyl}pyridine-3-carboxylate (CAS 478033-22-6)
- (2R,3R)-2-(2-chlorophenyl)-1-methyl-5-oxopyrrolidine-3-carboxylic acid (CAS 1020073-50-0)
- Ethyl 4-bromo-1-(2,2,2-trifluoroethyl)-1H-pyrazole-5-carboxylate (CAS 1856032-49-9)
- 2-(2-Methyl-4-phenylthiazol-5-yl)ethan-1-amine (CAS 1017486-41-7)
- Methyl 2-(((benzyloxy)carbonyl)amino)-3-iodopropanoate (CAS 1822420-54-1)
- Hydrocortisone 17-Butyrate 21-Propionate (CAS 72590-77-3)
- Vasonatrin Peptide (VNP) trifluoroacetate salt (CAS 141676-35-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com