Erlotinib Impurity 105 CAS 33432-52-9
| CAS No. | 33432-52-9 |
| Molecular Formula | C11H11NO3 |
| Molecular Weight | 205.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Erlotinib Impurity 105 (C11H11NO3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Erlotinib Impurity 105 (CAS 33432-52-9) is a certified pharmaceutical impurity reference standard with the molecular formula C11H11NO3 and a molecular weight of 205.21 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Erlotinib Impurity 105 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H11NO3 |
| Molecular Weight | 205.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Nitrogen Atoms | 1 |
Related Erlotinib Standards
- Erlotinib Impurity 61 (CAS 20825-87-0)
- Erlotinib impurity 130 (CAS 585-79-5)
- Erlotinib Impurity 78 (CAS 174674-93-2)
- Erlotinib Impurity 79 (CAS 382150-30-3)
- Erlotinib Impurity 87 (CAS CATO-C4X-106987)
- Erlotinib Impurity 123 (CAS 1145671-36-8)
- Erlotinib Impurity 112 (CAS 555-68-0)
- Erlotinib Impurity 51 (CAS 115665-66-2)
Recommended Standards
- 2-(Acetylamino)-3-phenyl-2-propenoic acid (CAS 5469-45-4)
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- Bumetanide Impurity 54 (CAS CATO-C4X-198654)
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- Vinpocetine Impurity 4 (CAS 27773-65-5)
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