Loxoprofen Impurity 66 CAS 334948-52-6
| CAS No. | 334948-52-6 |
| Molecular Formula | C13H18O8 |
| Molecular Weight | 302.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 302.28 g/mol gives Loxoprofen Impurity 66 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Loxoprofen Impurity 66 (CAS 334948-52-6, C13H18O8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system, Loxoprofen Impurity 66 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 302.28 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Loxoprofen Impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H18O8 |
| Molecular Weight | 302.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
Related Loxoprofen Standards
- Loxoprofen impurity 85 (CAS 335096-46-3)
- Loxoprofen Impurity 132 (CAS CATO-C4X-1488132)
- Loxoprofen Impurity 70 (CAS 1027957-36-3)
- Loxoprofen Impurity 7 (CAS CATO-C4X-14887)
- Loxoprofen Impurity 77 (CAS CATO-C4X-148877)
- Loxoprofen Impurity 78 (CAS CATO-C4X-148878)
- Loxoprofen impurity 124 (CAS CATO-C4X-1488124)
- Loxoprofen Impurity 161 (CAS CATO-C4X-1488161)
Recommended Standards
- Valproate Impurity 68 (CAS CATO-C4X-116668)
- Valproate Impurity 67 (CAS CATO-C4X-116667)
- 2-amino-1-(2-methoxy-4-nitro-5-phenoxyphenyl)ethan-1-one (CAS CATO-C4X-1826142)
- Baclofen impurity 44 (CAS CATO-C4X-101244)
- Isavuconazole Impurity N15 (CAS 1443-80-7)
- Brexpiprazole Impurity 153 (CAS CATO-C4X-1131153)
- Tenofovir disoproxil Impurity 3 (CAS 211364-69-1（free base）)
- 1-(2,4-Dichloro-5-fluorophenyl)ethane-1-sulfonyl chloride (CAS 1247732-84-8)
- 4-Chloro-5-(hexylamino)-2-phenylpyridazin-3(2H)-one (CAS 923027-34-3)
- 1,1-Disulfanediylbis(naphthalen-2-ol) (CAS 42521-82-4)
- 1-Methyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridine (CAS 188998-38-1)
- 8,11-Dimethoxy-13-(3-(trifluoromethyl)benzyl)-6,13-dihydro-5H-indolo[3,2-c]acridine (CAS 860787-16-2)
- Sitafloxacin impurity 81 (CAS CATO-C4X-115581)
- Gastric Inhibitory Polypeptide (6-30) amide (human) (CAS 1139691-72-7)
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