Spironolactone EP Impurity E CAS 33784-05-3
| CAS No. | 33784-05-3 |
| Molecular Formula | C24H32O4S |
| Molecular Weight | 416.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Spironolactone EP Impurity E.
CATO supplies Spironolactone EP Impurity E (CAS 33784-05-3), a pharmacopoeial impurity reference standard (molecular formula C24H32O4S, MW 416.57 g/mol) used for the identification and quantification of trace impurities in APIs.
Spironolactone EP Impurity E (C24H32O4S) contains a flavonoid core, a sulfone group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Spironolactone EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H32O4S |
| Molecular Weight | 416.57 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Sulfur Atoms | 1 |
Related Spironolactone Standards
- Spironolactone (CAS 52-01-7)
- Spironolactone EP Impurity A (CAS 132458-33-4)
- Spironolactone D3 (CAS 52-01-7 (Unlabeled))
- Spironolactone EP Impurity I (CAS CATO-C4X-13459)
- Spironolactone Impurity 14 (CAS 53866-20-9)
- Spironolactone-d7(Major) (CAS CATO-CCAD302541)
- Spironolactone Impurity 20 (CAS CATO-C4X-134520)
- Spironolactone EP Impurity G (CAS 880106-10-5)
Recommended Standards
- Quetiapine impurity 73 (CAS CATO-C4X-124473)
- Captopril EP Impurity I (CAS CATO-C4X-119018)
- 1-(4-Hydroxy-3,5-dimethylphenyl)-2-((5-(4-pentylcyclohexyl)-1,3,4-oxadiazol-2-yl)thio)ethan-1-one (CAS 860611-09-2)
- Captopril impurity 1 (CAS CATO-C4X-11901)
- Folic Acid EP Impurity F (CAS 1391194-56-1)
- Cisatracurium Besilate EP Impurity Q Besylate (CAS CATO-C4X-1850121)
- Thioctic Acid Impurity N8 (CAS 41443-60-1)
- Ethyl 4-(aminomethyl)cyclohexane-1-carboxylate (CAS 104571-72-4)
- 3-Bromo-1-(tetrahydro-2H-pyran-2-yl)-5-(1-trityl-1H-1,2,4-triazol-3-yl)-1H-indazole (CAS 395102-98-4)
- 7-Fluoro-1H-indole-3-carbonitrile (CAS 1043601-55-3)
- 2-Bromopyrimidine-5-carboxamide (CAS 1209458-32-1)
- (S)-2-Amino-N-((1-benzylpyrrolidin-2-yl)methyl)-N-isopropylacetamide (CAS 1354017-98-3)
- 2-Bromo-1-(5-chloro-2-hydroxyphenyl)ethan-1-one (CAS 52727-99-8)
- Palmitoyl Tripeptide-8 TFA salt (CAS 936544-53-5)
Why CATO?
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