Spironolactone EP Impurity I CAS CATO-C4X-13459
| CAS No. | CATO-C4X-13459 |
| Molecular Formula | C24H36O4S |
| Molecular Weight | 420.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Spironolactone EP Impurity I meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Spironolactone EP Impurity I (CAS CATO-C4X-13459), a pharmacopoeial impurity reference standard (molecular formula C24H36O4S, MW 420.61 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Spironolactone EP Impurity I (C24H36O4S) contains a flavonoid core, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 420.61 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C24H36O4S |
| Molecular Weight | 420.61 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Sulfur Atoms | 1 |
Related Spironolactone Standards
- Spironolactone D3 (CAS 52-01-7 (Unlabeled))
- Spironolactone-d7(Major) (CAS CATO-CCAD302541)
- Spironolactone EP Impurity E (CAS 33784-05-3)
- Spironolactone (CAS 52-01-7)
- Spironolactone EP Impurity A (CAS 132458-33-4)
- Spironolactone Impurity 14 (CAS 53866-20-9)
- Spironolactone Impurity 20 (CAS CATO-C4X-134520)
- Spironolactone EP Impurity G (CAS 880106-10-5)
Recommended Standards
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- Bimatoprost-d5 (CAS CATO-CCAD302842)
- (2S,3R,4S,5R)-2-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate (CAS 128377-34-4)
- Dacomitinib Impurity 36 (CAS CATO-C4X-208636)
- Rivaroxaban Impurity 161 (CAS 482305-98-6)
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- 3-(4-Bromophenyl)-4-methylpentanoic acid (CAS 1017195-23-1)
- 3-Chloro-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (CAS 1956369-87-1)
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- 5-Acetylisothiazole (CAS 3684-00-2)
- 3,5-Dimethyl-1-((1-methyl-1h-1,2,4-triazol-5-yl)methyl)-1h-pyrazol-4-amine (CAS 1492726-91-6)
- Ac, Gastrin Releasing Peptide (20-27), porcine (CAS 77714-20-6)
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