8-Chloro-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl acetate CAS 338748-51-9
| CAS No. | 338748-51-9 |
| Molecular Formula | C9H5ClF3N3O2 |
| Molecular Weight | 279.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
8-Chloro-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl acetate (CAS 338748-51-9) is a high-purity analytical reference standard with the molecular formula C9H5ClF3N3O2 and a molecular weight of 279.60 g/mol.
The molecular framework of 8-Chloro-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl acetate (C9H5ClF3N3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 8-Chloro-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl acetate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H5ClF3N3O2 |
| Molecular Weight | 279.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- Methyl 5-chloro-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 120503-12-0)
- 3-Chloro-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid (CAS 866039-33-0)
- 3-Chloro-5-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (CAS 524036-11-1)
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Recommended Standards
- Ethyltris(dimethylsiloxy)silane (CAS 150320-87-9)
- 5-(Chloromethyl)-3-(4-fluoro-2-(trifluoromethyl)phenyl)isoxazole (CAS 858939-35-2)
- Prothioconazole Impurity N7 (CAS 134818-67-0)
- 3-Chloro-7-fluoro-5-nitro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide (CAS 1437481-62-3)
- 5-Cyclopropyl-N-((5-(furan-2-carbonyl)thiophen-2-yl)methyl)isoxazole-3-carboxamide (CAS 1797613-36-5)
- 4-(Pyridin-4-yl)oxazole (CAS 681135-59-1)
- 1-Boc-4-[(4-cyanophenyl)amino]-piperidine (CAS 333986-52-0)
- N-(cyclohexylmethyl)aniline (CAS 79952-92-4)
- 2-Chloro-6-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine (CAS 1356087-32-5)
- N-Methyl-N-[(3R)-pyrrolidin-3-yl]methanesulfonamide (CAS 1419075-92-5)
- 4-Bromo-2-(3-pyrrolinomethyl) benzophenone (CAS 898763-08-1)
- 4-ethynylpiperidine (CAS 738577-08-7)
- [3-cyano-6-(isopropylamino)pyrazolo[1,5-a]pyridin-4-yl] trifluoromethanesulfonate (CAS 2649420-25-5)
- D-[Ser]8-Liraglutide (CAS CATO-C4X-199238)
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