8-Chloro-5-fluoro-4-methoxy-2-(trifluoromethyl)quinoline CAS 917251-95-7
| CAS No. | 917251-95-7 |
| Molecular Formula | C11H6ClF4NO |
| Molecular Weight | 279.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 8-Chloro-5-fluoro-4-methoxy-2-(trifluoromethyl)quinoline is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
8-Chloro-5-fluoro-4-methoxy-2-(trifluoromethyl)quinoline (CAS 917251-95-7), molecular formula C11H6ClF4NO and molecular weight 279.62 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 8-Chloro-5-fluoro-4-methoxy-2-(trifluoromethyl)quinoline is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 279.62 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 8-Chloro-5-fluoro-4-methoxy-2-(trifluoromethyl)quinoline under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H6ClF4NO |
| Molecular Weight | 279.62 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 3-(4-Chloro-2-fluoro-5-methylphenyl)-5-(trifluoromethyl)isoxazole (CAS 653569-92-7)
- 3-Chloro-5-fluoro-7-nitro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide (CAS 1437458-04-2)
- 3-Chloro-7-fluoro-5-nitro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide (CAS 1437481-62-3)
- 5-Chloro-2-((5-nitrofuran-2-yl)oxy)benzofuran (CAS 89266-67-1)
- Methyl 5-chloro-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 120503-12-0)
- 2-[3-chloro-5-methoxy-4-(2,2,2-trifluoroethoxy)phenyl]acetonitrile (CAS 1209937-54-1)
- 3-Chloro-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid (CAS 866039-33-0)
- 3-Chloro-5-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (CAS 524036-11-1)
Recommended Standards
- 5-(Chloromethyl)-3-(4-fluoro-2-(trifluoromethyl)phenyl)isoxazole (CAS 858939-35-2)
- Ethyltris(dimethylsiloxy)silane (CAS 150320-87-9)
- (4-Bromo-2-chlorophenoxy)trimethylsilane (CAS 809278-96-4)
- 8-Chloro-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl acetate (CAS 338748-51-9)
- 3-Chloro-5-fluorobenzenesulfonyl chloride (CAS 1131397-73-3)
- (6-(4-(Naphthalen-1-yl)phenyl)pyren-1-yl)boronic acid (CAS 2031254-18-7)
- 3-(1,3,5-Trimethyl-1H-pyrazol-4-yl)propanoic acid hydrochloride (CAS 1269087-62-8)
- 1-(2,6-difluorophenyl)ethane-1,2-diamine dihydrochloride (CAS 2044927-43-5)
- Ethyl (E)-1-benzyl-4-(hydroxyimino)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate (CAS 1243149-22-5)
- Tebipenem pivoxil Impurity P6 (CAS 1665289-91-7)
- 2-((2,4-Dichlorobenzyl)thio)-8-methyl-4H-pyrido[1,2-a][1,3,5]triazin-4-one (CAS 896337-10-3)
- 4-(Aminomethyl)benzohydrazide (CAS 35008-93-6)
- 2-(Isopropylthio)-1-(2-methoxyphenyl)ethan-1-one (CAS 1184288-35-4)
- D-[Ala]24-Semaglutide (CAS CATO-C4X-2226126)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com