1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N'-[(1E)-phenylmethylidene]piperidine-4-carbohydrazide CAS 338761-40-3
| CAS No. | 338761-40-3 |
| Molecular Formula | C19H18ClF3N4O |
| Molecular Weight | 410.82 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N'-[(1E)-phenylmethylidene]piperidine-4-carbohydrazide (CAS 338761-40-3) is a high-purity analytical reference standard with the molecular formula C19H18ClF3N4O and a molecular weight of 410.82 g/mol.
The molecular framework of 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N'-[(1E)-phenylmethylidene]piperidine-4-carbohydrazide (C19H18ClF3N4O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H18ClF3N4O |
| Molecular Weight | 410.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloro Standards
- N-(4-Chloro-3-pyridyl)-4-[[2,2-difluorobenzo[d][1,3]dioxol-5-yl]methyl]piperazine-1-carboxamide (CAS 1346528-50-4)
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Recommended Standards
- N-(4-Fluorophenyl){[1-(2-chloro-4-nitrophenyl)-1H-pyrrol-2-yl]amino}sulfonamide (CAS 860650-12-0)
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- 5-(4-Chlorophenyl)-2-methyl-3-(4-oxo-4H-chromen-3-yl)tetrahydro-4H-pyrrolo[3,4-d]isoxazole-4,6(5H)-dione (CAS 318949-31-4)
- 4-(4-(Tert-butyl)phenyl)-2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (CAS 860612-54-0)
- 4-(2,4,5-Trimethylphenyl)thiazole-2-carbaldehyde (CAS 383144-14-7)
- 2-Amino-1-(4-(isopropyl(methyl)amino)piperidin-1-yl)ethanone (CAS 1353958-78-7)
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- 2-((Methyl-d3)-2-pyridinylamino)ethanol (CAS 1190016-14-8)
- 3-[(3,4-Dichlorophenyl)amino]-1-(4-methoxyphenyl)propan-1-one (CAS 135779-25-8)
- 180340-69-6 2-amino-3-bromo-5-pyridinecarboxylic acid 6-Amino-5-bromonicotinicacid 6-amino-5-bromonicotinic acid 6-amino-5-bromopyridine-3-carboxylic acid (CAS 180340-69-6)
- Chlorphenamine Impurity 27 (CAS 339114-86-2)
- (R)-1-(5-Bromopyridin-2-yl)ethan-1-ol (CAS 870694-36-3)
- N-[(S)-1-(2-Chloro-acetyl)-pyrrolidin-2-ylmethyl]-N-ethyl-acetamide (CAS 1353997-03-1)
- Peptide Impurity 12 (CAS CATO-CPTD788812)
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