N-[(4-Chlorophenyl)methyl]-2-oxo-1-{[4-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridine-3-carboxamide CAS 338782-35-7
| CAS No. | 338782-35-7 |
| Molecular Formula | C21H16ClF3N2O2 |
| Molecular Weight | 420.81 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
N-[(4-Chlorophenyl)methyl]-2-oxo-1-{[4-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridine-3-carboxamide (CAS 338782-35-7) is a high-purity analytical reference standard with the molecular formula C21H16ClF3N2O2 and a molecular weight of 420.81 g/mol.
The molecular framework of N-[(4-Chlorophenyl)methyl]-2-oxo-1-{[4-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridine-3-carboxamide (C21H16ClF3N2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H16ClF3N2O2 |
| Molecular Weight | 420.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related N Standards
- 2-[1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-oxo-N-[4-(trifluoromethyl)phenyl]acetamide (CAS 866152-59-2)
- 2-(4-Chlorophenyl)-N-((dimethylamino)methylene)-2-(3-(trifluoromethyl)quinoxalin-2-yl)acetamide (CAS 338412-27-4)
- 2-((5-(2-Chlorophenyl)-1,3,4-oxadiazol-2-yl)thio)-N-(2-methoxy-4-nitrophenyl)acetamide (CAS 332160-29-9)
- 3-(4-((1-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-yl)methoxy)-3,5-difluorophenyl)-2-methylpropanoic acid (CAS 1224102-50-4)
- 2-(4-Chlorophenyl)-7-ethoxy-5-(4-nitrophenyl)-3H-benzo[e][1,2,4]triazepine (CAS 444159-02-8)
- (4-Chlorophenyl)(3-(1-((2-fluoro-[1,1'-biphenyl]-4-yl)oxy)ethyl)-1H-pyrazol-1-yl)methanone (CAS 477709-14-1)
- (5Z)-5-{[(2-chlorophenyl)amino]methylidene}-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one (CAS 339096-93-4)
- (5Z)-5-{[(3-chlorophenyl)amino]methylidene}-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one (CAS 339096-94-5)
Recommended Standards
- N-(4-chlorobenzyl)-4-((2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)methyl)benzamide (CAS 339025-02-4)
- N-benzyl-1-(4-chlorobenzyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide (CAS 551921-71-2)
- N-(3-chloro-2-methylphenyl)-4-((2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)methyl)benzamide (CAS 339025-34-2)
- N-Benzyl-5-chloro-6-oxo-1-{[3-(trifluoromethyl)phenyl]methyl}-1,6-dihydropyridine-3-carboxamide (CAS 339024-21-4)
- (2-Chloro-6-(difluoromethyl)-3-iodopyridin-4-yl)methanol (CAS 1805387-79-4)
- 6-chloro-N-(3,5-difluorophenyl)pyridine-3-sulfonamide (CAS 1041507-44-1)
- Tert-butyl 1',4'-dihydro-2'H-spiro[piperidine-3,3'-quinoline]-1-carboxylate (CAS 189320-53-4)
- 3-Ethyl-sydnone imine hydrochloride (CAS 5596-04-3)
- Spiro[2.5]octane-4,8-dione (CAS 60582-68-5)
- Methyl (3-bromo-1H-1,2,4-triazol-1-yl)acetate (CAS 709021-70-5)
- 2-Chloro-5-(3-(trifluoromethyl)phenyl)isonicotinic acid (CAS 1261773-33-4)
- Methyl (s)-2'-oxo-1'-phenyl-3,4-dihydro-1h-spiro[naphthalene-2,3'-piperidine]-6-carboxylate (CAS 2028324-99-2)
- 18014-78-3 6038AD C11H12ClNO2 N-(2-Acetylphenyl)-3-chloropropanamide (CAS 18014-78-3)
- Semaglutide impurity 85 (CAS CATO-C4X-222685)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com