Methyl 2-{5-chloro-1-[(4-chlorophenyl)methyl]-2-oxo-1,2-dihydropyridine-3-amido}benzoate CAS 338977-29-0
| CAS No. | 338977-29-0 |
| Molecular Formula | C21H16Cl2N2O4 |
| Molecular Weight | 431.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl 2-{5-chloro-1-[(4-chlorophenyl)methyl]-2-oxo-1,2-dihydropyridine-3-amido}benzoate.
CATO supplies Methyl 2-{5-chloro-1-[(4-chlorophenyl)methyl]-2-oxo-1,2-dihydropyridine-3-amido}benzoate (CAS 338977-29-0), a certified reference material (molecular formula C21H16Cl2N2O4, MW 431.27 g/mol) for analytical method development and quality control.
The molecular framework of Methyl 2-{5-chloro-1-[(4-chlorophenyl)methyl]-2-oxo-1,2-dihydropyridine-3-amido}benzoate (C21H16Cl2N2O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Methyl 2-{5-chloro-1-[(4-chlorophenyl)methyl]-2-oxo-1,2-dihydropyridine-3-amido}benzoate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H16Cl2N2O4 |
| Molecular Weight | 431.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Methyl Standards
- Methyl 2-{5-chloro-1-[(3-chlorophenyl)methyl]-6-oxo-1,6-dihydropyridine-3-amido}benzoate (CAS 338977-31-4)
- Methyl 4-{5-chloro-1-[(3-chlorophenyl)methyl]-6-oxo-1,6-dihydropyridine-3-amido}benzoate (CAS 338977-49-4)
- 4-Chloro-N-[2-(6-chloro-4-trifluoromethyl-pyridin-2-ylsulfanyl)-ethyl]-benzenesulfonamide (CAS 1311280-25-7)
- 3-[(1E)-{[(5-chloro-1,2,3-thiadiazol-4-yl)methoxy]amino}methylidene]-1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]thiourea (CAS 477885-60-2)
- 4-Chloro-5-(4-(3-chlorophenyl)piperazin-1-yl)-2-(4-methoxyphenyl)pyridazin-3(2H)-one (CAS 477867-46-2)
- 3-Benzyl-1-(3-chloro-4-fluorophenyl)-1-(2-hydroxy-3-methoxybenzyl)thiourea (CAS 306730-50-7)
- 1-[(2-Chloro-6-fluorophenyl)methoxy]-3-[(3,4-dichlorophenyl)methyl]imidazolidine-2,4,5-trione (CAS 303986-58-5)
- 3-(4-Chloro-3-(trifluoromethyl)phenyl)-2-mercapto-7-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3h)-one (CAS 723333-49-1)
Recommended Standards
- Methyl 2-{1-[(2,4-dichlorophenyl)methyl]-2-oxo-1,2-dihydropyridine-3-amido}benzoate (CAS 338977-61-0)
- Axitinib Impurity 20 (CAS CATO-C4X-107120)
- Methyl 2-(1-(2,4-dichlorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamido)benzoate (CAS 242797-49-5)
- Boc-(R)-γ-(4-iodo-benzyl)-L-proline (CAS 959573-98-9)
- 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carbonitrile hydrochloride (CAS 2116848-05-4)
- Ethyl 3-aminopropanoate (CAS 924-73-2)
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- 2-(((2-Methylquinolin-4-yl)amino)methylene)-1H-indene-1,3(2H)-dione (CAS 1024127-32-9)
- 2,2,2-Trifluoro-1-(2-(methylamino)phenyl)ethanone (CAS 202270-41-5)
- Peptide 46 (H-4054.0500) (CAS 192122-40-0)
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