Methyl 2-{5-chloro-1-[(3-chlorophenyl)methyl]-6-oxo-1,6-dihydropyridine-3-amido}benzoate CAS 338977-31-4
| CAS No. | 338977-31-4 |
| Molecular Formula | C21H16Cl2N2O4 |
| Molecular Weight | 431.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Methyl 2-{5-chloro-1-[(3-chlorophenyl)methyl]-6-oxo-1,6-dihydropyridine-3-amido}benzoate is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Methyl 2-{5-chloro-1-[(3-chlorophenyl)methyl]-6-oxo-1,6-dihydropyridine-3-amido}benzoate (CAS 338977-31-4), a certified reference material (molecular formula C21H16Cl2N2O4, MW 431.27 g/mol) for analytical method development and quality control.
Methyl 2-{5-chloro-1-[(3-chlorophenyl)methyl]-6-oxo-1,6-dihydropyridine-3-amido}benzoate (C21H16Cl2N2O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Methyl 2-{5-chloro-1-[(3-chlorophenyl)methyl]-6-oxo-1,6-dihydropyridine-3-amido}benzoate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H16Cl2N2O4 |
| Molecular Weight | 431.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Methyl Standards
- Methyl 2-{5-chloro-1-[(4-chlorophenyl)methyl]-2-oxo-1,2-dihydropyridine-3-amido}benzoate (CAS 338977-29-0)
- Methyl 4-{5-chloro-1-[(3-chlorophenyl)methyl]-6-oxo-1,6-dihydropyridine-3-amido}benzoate (CAS 338977-49-4)
- 4-Chloro-N-[2-(6-chloro-4-trifluoromethyl-pyridin-2-ylsulfanyl)-ethyl]-benzenesulfonamide (CAS 1311280-25-7)
- 3-[(1E)-{[(5-chloro-1,2,3-thiadiazol-4-yl)methoxy]amino}methylidene]-1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]thiourea (CAS 477885-60-2)
- 4-Chloro-5-(4-(3-chlorophenyl)piperazin-1-yl)-2-(4-methoxyphenyl)pyridazin-3(2H)-one (CAS 477867-46-2)
- 3-Benzyl-1-(3-chloro-4-fluorophenyl)-1-(2-hydroxy-3-methoxybenzyl)thiourea (CAS 306730-50-7)
- 1-[(2-Chloro-6-fluorophenyl)methoxy]-3-[(3,4-dichlorophenyl)methyl]imidazolidine-2,4,5-trione (CAS 303986-58-5)
- 3-(4-Chloro-3-(trifluoromethyl)phenyl)-2-mercapto-7-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3h)-one (CAS 723333-49-1)
Recommended Standards
- Methyl 2-{1-[(2,4-dichlorophenyl)methyl]-2-oxo-1,2-dihydropyridine-3-amido}benzoate (CAS 338977-61-0)
- Methyl 2-(1-(2,4-dichlorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamido)benzoate (CAS 242797-49-5)
- Boc-(R)-γ-(4-iodo-benzyl)-L-proline (CAS 959573-98-9)
- Axitinib Impurity 20 (CAS CATO-C4X-107120)
- 1-(4-Chlorophenyl)-3-(5-((4-methoxyphenyl)amino)-4H-1,2,4-triazol-3-yl)urea (CAS 860787-23-1)
- 1,3-Dimorpholinopropane-1,3-dione (CAS 10256-01-6)
- 2-Amino-5-chloro-4-methoxybenzoic Acid (CAS 79025-82-4)
- 1,1-dioxo-1λ⁶-thiolan-3-yl 2-chloroacetate (CAS 869716-12-1)
- 1,3-Diethyl 2-(2-Azidoethyl)propanedioate (CAS 131325-86-5)
- (5E)-5-[(2H-1,3-Benzodioxol-5-yl)methylidene]-2-[(prop-2-en-1-yl)amino]-4,5-dihydro-1,3-thiazol-4-one (CAS 866154-27-0)
- Isavuconazole Impurity 6 (CAS CATO-C4X-12366)
- 1-[2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-1H-indole-2,3-dione (CAS 303065-17-0)
- Ethyl 6-(bromomethyl)nicotinate (CAS 178264-57-8)
- Peptide 74 (H-8545.0500) (CAS 132116-39-3)
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