4-Chloro-6-[4-(2-chlorophenyl)piperazin-1-yl]-2-(methylsulfanyl)pyrimidine CAS 339017-77-5
| CAS No. | 339017-77-5 |
| Molecular Formula | C15H16Cl2N4S |
| Molecular Weight | 355.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 4-Chloro-6-[4-(2-chlorophenyl)piperazin-1-yl]-2-(methylsulfanyl)pyrimidine (CAS 339017-77-5), a certified reference material (molecular formula C15H16Cl2N4S, MW 355.29 g/mol) for analytical method development and quality control.
The molecular framework of 4-Chloro-6-[4-(2-chlorophenyl)piperazin-1-yl]-2-(methylsulfanyl)pyrimidine (C15H16Cl2N4S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H16Cl2N4S |
| Molecular Weight | 355.29 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 4-Chloro-2-{[(4-chlorophenyl)sulfanyl]methyl}-5,6-dimethylthieno[2,3-d]pyrimidine (CAS 793727-83-0)
- 4-Chloro-5-((4-chlorobenzyl)oxy)-2-hexylpyridazin-3(2H)-one (CAS 88094-41-1)
- Methyl 3-chloro-4-((4-chlorobenzyl)oxy)-5-ethoxybenzoate (CAS 1706458-12-9)
- 2-Chloro-1-[4-(3-chloro-4-fluorobenzenesulfonyl)piperazin-1-yl]ethan-1-one (CAS 923780-46-5)
- 6-Chloro-3-(4-chlorobenzenesulfonyl)-2H-chromen-2-one (CAS 866013-21-0)
- Methyl 2-(2-chloro-6-fluorophenyl)-4-(4-chlorophenyl)-4-oxobutanoate (CAS 344281-42-1)
- 6-Chloro-3-iodo-2-phenylimidazo[1,2-b]pyridazine (CAS 1023697-90-6)
- 6-Chloro-2-(4-iodophenyl)imidazo[1,2-b]pyridazine (CAS 188692-40-2)
Recommended Standards
- 5''-Bromo-[2,2':5',2''-terthiophene]-5-carbaldehyde (CAS 161726-69-8)
- 5-(4-Bromophenyl)-1-[3-(propan-2-yloxy)propyl]-1h-imidazole-2-thiol (CAS 793716-12-8)
- (R)-N-((R)-1-(7-Bromoquinolin-2-yl)ethyl)-2-methylpropane-2-sulfinamide (CAS 1509906-60-8)
- 5-Bromo-N-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide (CAS 439108-11-9)
- 2-(2-Methoxyethyl)-5,6,7,8-tetrahydropyrido[4,3-c]pyridazin-3(2h)-one (CAS 1282786-48-4)
- 2-Bromo-3-methoxy-6-nitropyridine (CAS 76066-07-4)
- 1H-INDOLE, 7-BROMO- 51417-51-7 7-BROMINDOL 7-BROMO-1H-INDOLE 7-BROMOINDOLE BC003235 (CAS 51417-51-7)
- Bis(1H-benzo[d]imidazol-1-yl)dimethylsilane (CAS 1858256-89-9)
- 2-(3,5-Dimethylfuran-2-yl)piperazine (CAS 111781-41-0)
- 3-(adamantan-1-yl)-3-aminopropan-1-ol hydrochloride (CAS 1803601-82-2)
- Dacomitinib Impurity 7 (CAS CATO-C4X-20867)
- 2-(4-Aminophenyl)-6-methylbenzo[d]thiazole-7-sulfonic acid (CAS 130-17-6)
- 3-Ethoxybenzaldehyde (CAS 22924-15-8)
- Semaglutide impurity 57 (CAS 2773558-06-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com