Dacomitinib Impurity 7 CAS CATO-C4X-20867
| CAS No. | CATO-C4X-20867 |
| Molecular Formula | C24H25ClFN5O2 |
| Molecular Weight | 469.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C24H25ClFN5O2, Dacomitinib Impurity 7 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 469.94 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Dacomitinib Impurity 7 (CAS CATO-C4X-20867, C24H25ClFN5O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Dacomitinib Impurity 7 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H25ClFN5O2 |
| Molecular Weight | 469.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Dacomitinib Standards
- Dacomitinib (CAS 1110813-31-4)
- Dacomitinib Impurity 28 (CAS CATO-C4X-208628)
- Dacomitinib Impurity 32 (CAS CATO-C4X-208632)
- Dacomitinib Impurity 38 (CAS CATO-C4X-208638)
- Dacomitinib Impurity 9 (CAS CATO-C4X-20869)
- Dacomitinib Impurity 47 (CAS CATO-C4X-208647)
- Dacomitinib Impurity 45 (CAS CATO-C4X-208645)
- Dacomitinib Impurity 51 (CAS CATO-C4X-208651)
Recommended Standards
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- Meclozine EP Impurity B (CAS 119-56-2)
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- 2-[(1,3-thiazol-2-ylmethyl)sulfanyl]ethan-1-ol (CAS 1537687-01-6)
- Semaglutide Impurity 138 (CAS CATO-C4X-2226138)
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