2-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]sulfanyl}-N-(2-phenoxyethyl)nicotinamide CAS 339278-11-4
| CAS No. | 339278-11-4 |
| Molecular Formula | C20H15ClF3N3O2S |
| Molecular Weight | 453.87 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]sulfanyl}-N-(2-phenoxyethyl)nicotinamide.
CATO supplies 2-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]sulfanyl}-N-(2-phenoxyethyl)nicotinamide (CAS 339278-11-4), a certified reference material (molecular formula C20H15ClF3N3O2S, MW 453.87 g/mol) for analytical method development and quality control.
The molecular framework of 2-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]sulfanyl}-N-(2-phenoxyethyl)nicotinamide (C20H15ClF3N3O2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]sulfanyl}-N-(2-phenoxyethyl)nicotinamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H15ClF3N3O2S |
| Molecular Weight | 453.87 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related chloro Standards
- 2-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperidin-4-ylidene}-N-[(phenylcarbamoyl)amino]acetamide (CAS 338761-64-1)
- 4-(2-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-4,5-dihydro-1H-imidazol-1-yl)benzoic acid (CAS 338412-07-0)
- 8-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-oxo-N-phenyl-1,2,8-triazaspiro[4.5]Decane-1-carboxamide (CAS 400076-23-5)
- 2-(2-((2-Chloro-7-methylquinolin-3-yl)methylene)hydrazinyl)-3-(o-tolyl)quinazolin-4(3H)-one (CAS 327039-01-0)
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- 4-Chloro-N-[(4-methyl-5-{[(4-nitrophenyl)methyl]sulfanyl}-4H-1,2,4-triazol-3-yl)methyl]benzene-1-sulfonamide (CAS 338421-52-6)
- n-(2-Chloro-5-(morpholinosulfonyl)phenyl)-2-((2-methoxybenzyl)amino)acetamide (CAS 735303-95-4)
Recommended Standards
- 2-((4-Allyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-chloro-3-(trifluoromethyl)phenyl)acetamide (CAS 587004-42-0)
- Flucloxacillin - API Standards (CAS 5250-39-5)
- 2-((4-Allyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-chloro-5-(trifluoromethyl)phenyl)acetamide (CAS 618880-11-8)
- Flucloxacillin Monohydrate EP Impurity I (CAS CATO-C4X-164719)
- 1-Bromo-3-chloro-4-methyl-2-(methylthio)benzene (CAS 1809168-68-0)
- (R)-2-((1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)methoxy)acetic acid (CAS 1018826-66-8)
- tert-Butyl (5-bromothiazolo[5,4-b]pyridin-2-yl)carbamate (CAS 1067877-78-4)
- 2-Chloro-5-hydroxyisonicotinaldehyde, >97% (CAS 1060804-53-6)
- 1-Iodo-2,5-dimethoxy-4-methylbenzene (CAS 75056-76-7)
- 2,3-Dimethyl-6-azaspiro[4.5]Decane (CAS 956784-80-8)
- Ethyl 4-bromo-1-ethyl-3-methyl-1H-pyrazole-5-carboxylate (CAS 1019010-83-3)
- (4-Bromophenyl)(4-(thiomorpholinomethyl)phenyl)methanone (CAS 898782-61-1)
- (E)-5,5,5-Trifluoropent-3-en-2-one (CAS 101395-81-7)
- Semaglutide impurity 200 (CAS CATO-C4X-2226200)
Why CATO?
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