Proparacaine Impurity 19 CAS 343773-15-9
| CAS No. | 343773-15-9 |
| Molecular Formula | C10H12ClNO2 |
| Molecular Weight | 213.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Proparacaine Impurity 19 (C10H12ClNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 213.66 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Proparacaine Impurity 19 (CAS 343773-15-9, C10H12ClNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Proparacaine Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H12ClNO2 |
| Molecular Weight | 213.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Proparacaine Standards
- Proparacaine Impurity 9 (CAS 342044-71-7)
- Proparacaine Impurity 7 (CAS 35288-44-9)
- Proparacaine Impurity 6 (CAS 59691-15-5)
- Proparacaine Impurity 20 (CAS 1216179-28-0)
- Proparacaine Impurity 14 (CAS CATO-C4X-202714)
- Proparacaine Impurity 22 (CAS CATO-C4X-202722)
- Proparacaine Impurity 29 (CAS CATO-C4X-202729)
- Proparacaine Impurity 15 (CAS 2102411-30-1)
Recommended Standards
- Lidocaine impurity 64 (CAS 64585-19-9)
- Phenacetin Impurity 4 (CAS 53689-25-1)
- Palbociclib Impurity 180 (CAS 2777066-29-0)
- Lifitegrast Impurity 149 (CAS CATO-C4X-2409149)
- Bortezomib Impurity 8 (CAS 886979-81-3)
- Glycyrrhizic Acid Impurity 12 (CAS CATO-C4X-253712)
- Propafenone Impurity 10 (CAS 86383-32-6)
- Urushiol (15:3) (CAS 83543-37-7)
- 1-(2,3-Dihydro-1H-inden-2-yl)guanidine dihydrochloride (CAS 2007916-13-2)
- Duloxetine Impurity 49 (CAS 116817-79-9)
- 2-Oxabicyclo[3.2.1]octan-3-one (CAS 5724-61-8)
- 6-oxo-5,6-dihydropyridazine-3-carboxylic acid (CAS 952591-28-5)
- Fmoc-D-β-HoAsp(OtBu)-OH (CAS 1246651-90-0)
- D-γ-Glu20-Side-Tirzepatide (CAS CATO-CPTD788929)
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