Lidocaine impurity 64 CAS 64585-19-9
| CAS No. | 64585-19-9 |
| Molecular Formula | C10H12ClNO2 |
| Molecular Weight | 213.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Lidocaine impurity 64 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Lidocaine impurity 64 (CAS 64585-19-9), a pharmacopoeial impurity reference standard (molecular formula C10H12ClNO2, MW 213.66 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Lidocaine impurity 64 (C10H12ClNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H12ClNO2 |
| Molecular Weight | 213.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Lidocaine Standards
- Lidocaine EP Impurity D-d6 (CAS 1216698-89-3)
- Lidocaine Impurity 77 (CAS CATO-C4X-167977)
- Lidocaine impurity 66 (CAS CATO-C4X-167966)
- Lidocaine EP Impurity K (CAS 74634-66-5)
- Lidocaine EP Impurity G (CAS 42459-30-3)
- Lidocaine EP Impurity D (CAS 7728-40-7)
- Lidocaine Impurity 30 (CAS 21236-54-4)
- Lidocaine Impurity 67 (CAS CATO-C4X-167967)
Recommended Standards
- Palbociclib Impurity 180 (CAS 2777066-29-0)
- Proparacaine Impurity 19 (CAS 343773-15-9)
- Rivaroxaban Impurity 102 (CAS 28025-61-8)
- Phenacetin Impurity 4 (CAS 53689-25-1)
- Azelastine Impurity 48 (CAS CATO-C4X-139648)
- Crizotinib impurity 24 (CAS 141699-59-4)
- Montelukast EP Impurity A (CAS 220927-27-5)
- 6-Fluoro-2-methyl-5-nitroquinoline (CAS 79821-10-6)
- 4-(1,1-Diphenylethyl)pyridine (CAS 109975-61-3)
- Ethyl 3-((2-nitro-4-sulfamoylphenyl)amino)propanoate (CAS 1031519-77-3)
- Hesperidin Impurity 2 (CAS CATO-C4X-33272)
- 6-((3-(Trifluoromethyl)phenyl)amino)pyridine-3-sulfonic acid (CAS 38026-01-6)
- 4-Bromobenzo[d]thiazole-2-carbonitrile (CAS 1188023-00-8)
- (Des-Thr7)-Glucagon trifluoroacetate salt (CAS 1802078-28-9)
Why CATO?
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