Bupropion Impurity 49 CAS 535-80-8
| CAS No. | 535-80-8 |
| Molecular Formula | C7H5ClO2 |
| Molecular Weight | 156.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Bupropion Impurity 49 (CAS 535-80-8), a pharmacopoeial impurity reference standard (molecular formula C7H5ClO2, MW 156.57 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C7H5ClO2, Bupropion Impurity 49 contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 156.57 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5ClO2 |
| Molecular Weight | 156.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Bupropion Standards
- Bupropion Impurity 48 (CAS 34841-35-5)
- Bupropion Impurity 17 (CAS 10557-17-2)
- Bupropion Impurity 46 (CAS 119802-69-6)
- Bupropion USP Related Compound C (CAS 152943-33-4)
- Bupropion USP Related Compound F (CAS 857233-13-7)
- Bupropion Impurity 13 (CAS 92821-92-6)
- Bupropion Impurity 32 (CAS CATO-C4X-120332)
- Bupropion Impurity 80 (CAS CATO-C4X-120380)
Recommended Standards
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- Mesalazine EP Impurity L (CAS 118-91-2)
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- Tizanidine Impurity 52 (CAS CATO-C4X-144552)
- Salbutamol Impurity 113 (CAS CATO-C4X-1176113)
- Esomeprazole Impurity 46 (CAS 143016-70-0)
- Hydroxychloroquine impurity 62 (CAS CATO-C4X-183562)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com