Cinacalcet Impurity 51 CAS 349-75-7

Description

The occurrence of Cinacalcet Impurity 51 is closely related to a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

CATO supplies Cinacalcet Impurity 51 (CAS 349-75-7), a pharmacopoeial impurity reference standard (molecular formula C8H7F3O, MW 176.14 g/mol) used for the identification and quantification of trace impurities in APIs.

Owing to a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, Cinacalcet Impurity 51 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 176.14 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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