Cinacalcet Impurity 35 CAS 454-89-7
| CAS No. | 454-89-7 |
| Molecular Formula | C8H5F3O |
| Molecular Weight | 174.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 174.12 g/mol gives Cinacalcet Impurity 35 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Cinacalcet Impurity 35 (CAS 454-89-7, C8H5F3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Cinacalcet Impurity 35 (C8H5F3O) contains a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Cinacalcet Impurity 35 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5F3O |
| Molecular Weight | 174.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Cinacalcet Standards
- Cinacalcet Impurity 49 (CAS 447-61-0)
- Cinacalcet Impurity 29 (CAS 1020414-30-5)
- Cinacalcet Impurity 28 (CAS 802918-45-2)
- Cinacalcet Impurity 20 (CAS CATO-C4X-105920)
- Cinacalcet Impurity 21 (CAS CATO-C4X-105921)
- Cinacalcet impurity C1403 (CAS 851984-49-1)
- Cinacalcet Impurity 4 (CAS 7228-47-9)
- Cinacalcet Impurity 8 (CAS 1517-72-2)
Recommended Standards
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