2-Chloro-6-fluoro-3-methylphenylboronic Acid CAS 352535-85-4
| CAS No. | 352535-85-4 |
| Molecular Formula | C7H7BClFO2 |
| Molecular Weight | 188.39 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Chloro-6-fluoro-3-methylphenylboronic Acid (CAS 352535-85-4) is a high-purity analytical reference standard with the molecular formula C7H7BClFO2 and a molecular weight of 188.39 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 2-Chloro-6-fluoro-3-methylphenylboronic Acid is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 188.39 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H7BClFO2 |
| Molecular Weight | 188.39 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- (5-Chloro-2-fluoro-4-methylphenyl)boronic acid (CAS 1072952-42-1)
- 2-Chloro-4-fluoro-5-methylphenylboronic acid (CAS 1207428-93-0)
- (2-Chloro-6-fluorobenzyl)boronic acid (CAS 1350512-24-1)
- 2-Chloro-5-fluoro-4-methylphenylboronic acid (CAS 1612184-35-6)
- (3-Chloro-2-fluoro-4-methylphenyl)boronic acid (CAS 2377608-77-8)
- (3-Chloro-2-fluoro-5-methylphenyl)boronic acid (CAS 352535-88-7)
- (4-Chloro-2-fluoro-3-methylphenyl)boronic acid (CAS 944128-92-1)
- (4-Chloro-2-fluoro-5-methylphenyl)boronic acid (CAS 325786-09-2)
Recommended Standards
- 2-Chloro-5-fluoro-3-methylphenylboronic acid (CAS 2121511-44-0)
- 4-Chloro-3-fluoro-2-methylphenylboronic acid (CAS 2377606-88-5)
- 2-Chloro-4-fluoro-6-methylphenylboronic acid (CAS 2121514-96-1)
- 4-Chloro-5-fluoro-2-methylphenylboronic acid (CAS 2055778-22-6)
- 4'-Trifluoromethoxy-biphenyl-3-carbaldehyde (CAS 675596-34-6)
- n-(3,5-Difluorobenzyl)-1-(1-methyl-1h-pyrazol-4-yl)methanamine (CAS 1006436-32-3)
- 2-Bromo-5-fluoro-4-(trifluoromethyl)benzoic acid (CAS 2090964-98-8)
- (E)-4-((2-carboxyethyl)amino)-4-oxobut-2-enoic acid (CAS 904217-40-9)
- 2-Bromo-6-chloropyridin-4-amine (CAS 1060815-59-9)
- N-[(Hydroxyimino)methyl]-N-[(4-nitrobenzyl)oxy]urea (CAS 338404-33-4)
- H-Ala-Pro-Arg-Thr-Pro-Gly-Gly-Arg-Arg-OH trifluoroacetate salt (CAS 138028-00-9)
- 3-Hydroxy-3-(1,3-thiazol-2-yl)propanenitrile (CAS 1094405-17-0)
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- Neuropeptide S (rat) (CAS 412938-75-1)
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