Dopamine Impurity 74 HCl CAS 35266-63-8
| CAS No. | 35266-63-8 |
| Molecular Formula | C11H17NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Dopamine Impurity 74 HCl.
Dopamine Impurity 74 HCl (CAS 35266-63-8) is a certified pharmaceutical impurity reference standard with the molecular formula C11H17NO2HCl and a molecular weight of 231.72 g/mol.
Dopamine Impurity 74 HCl (C11H17NO2HCl) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H17NO2 HCl |
| Molecular Weight | 231.72 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Dopamine Standards
Recommended Standards
- Cholesterol Impurity 29 (CAS 881024-99-3)
- Prasugrel Impurity 33 (CAS CATO-C4X-108633)
- Bilastine Impurity 62 DiHCl (CAS 1789305-52-7(free base))
- 5-Methyl-2-hexene (cis- and trans- mixture) (CAS 7385-82-2)
- [2-methyl-4-(1h-pyrazol-1-yl)phenyl]methanol (CAS 1247367-86-7)
- Diquafosol Impurity 12 (CAS 19817-92-6)
- (2-Chloro-5-(difluoromethyl)phenyl)(pyridin-4-yl)methanone (CAS 1261768-61-9)
- Pentoxifylline EP Impurity K (CAS 74857-22-0)
- 3,6-Dicyclopropyl-1-(2-fluorophenyl)-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 1018164-66-3)
- Semaglutide impurity 34 (CAS CATO-C4X-222634)
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