Celecoxib Impurity 33 CAS 35282-78-1
| CAS No. | 35282-78-1 |
| Molecular Formula | C6H6N3O2S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Celecoxib Impurity 33 (CAS 35282-78-1, C6H6N3O2SCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Celecoxib Impurity 33 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 219.64 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H6N3O2S Cl |
| Molecular Weight | 219.64 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Celecoxib Standards
- Celecoxib Impurity 9 (CAS 1061214-06-9)
- Celecoxib Impurity 12 (CAS 1061214-09-2)
- Celecoxib Carboxylic Acid Methyl Ester (CAS 1189893-75-1)
- Celecoxib Impurity 38 (CAS 131774-72-6)
- Celecoxib Impurity 13 (CAS 1576-43-8)
- Celecoxib Impurity 22 (CAS 163266-02-2)
- Celecoxib (CAS 169590-42-5)
- Celecoxib Impurity 32 (CAS 170569-87-6)
Recommended Standards
- Risedronate EP Impurity B (CAS 105462-23-5)
- Dotinurad Impurity 256 (CAS CATO-C4X-2494256)
- Tafluprost Impurity 20 (CAS 3446-89-7)
- Tris(perfluorophenyl)silane (CAS 20160-40-1)
- 3-[1-(2H-1,3-Benzodioxole-5-carbonyl)piperidin-4-yl]-4-[(4-methylphenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775558-61-6)
- 1-((5-Chloro-1H-indol-3-yl)-methyl)piperidin-4-amine (CAS 1627727-99-4)
- Trimethoxy[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl]titanium (CAS 123927-75-3)
- (2-(2-Methylallyl)phenyl)boronic acid (CAS 372193-66-3)
- tert-Butyl 4-(hydrazinecarbonyl)azepane-1-carboxylate (CAS 1408074-80-5)
- Semaglutide impurity 274 (CAS CATO-C4X-2226274)
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