Vancomycin EP Impurity H CAS 357396-41-9
| CAS No. | 357396-41-9 |
| Molecular Formula | C66H76ClN9O24 |
| Molecular Weight | 1414.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Vancomycin EP Impurity H (CAS 357396-41-9), a pharmacopoeial impurity reference standard (molecular formula C66H76ClN9O24, MW 1414.81 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Vancomycin EP Impurity H (C66H76ClN9O24) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 33.0, corresponding to approximately 33 ring(s) or double-bond equivalent(s). With a molecular weight of 1414.81 g/mol, it falls into the high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Vancomycin EP Impurity H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C66H76ClN9O24 |
| Molecular Weight | 1414.81 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 33.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 9 |
Related Vancomycin Standards
- Vancomycin EP Impurity G (CAS CATO-C4X-17758)
- Vancomycin impurity 24 (CAS CATO-C4X-177524)
- Vancomycin EP Impurity A (CAS 91700-98-0(Free Base))
- Vancomycin impurity 23 (CAS CATO-C4X-177523)
- Vancomycin impurity 25 (CAS CATO-C4X-177525)
- Vancomycin EP Impurity I (CAS CATO-C4X-177510)
- Vancomycin EP Impurity J (CAS 2416251-24-4)
- Vancomycin Impurity M (CAS CATO-C4X-177522)
Recommended Standards
- Monodeschloro-Vancomycin (CAS CATO-C4X-17751)
- Tenofovir disoproxil Impurity 33 (CAS CATO-C4X-107633)
- 5,10,15,20-Tetrakis(3,5-dibromo-2,4,6-trimethylphenyl)-21H,23H-porphine (CAS 128014-51-7)
- Bleomycin - API Standards (CAS 11056-06-7)
- Ofloxacin EP Impurity E(HCl) (CAS 402930-70-5)
- Lasmiditan Impurity 58 (CAS CATO-C4X-247858)
- Irinotecan impurity 57 (CAS CATO-C4X-166757)
- Butyl 4-(5-formylfuran-2-yl)benzoate (CAS 321725-76-2)
- 2-Chloro-4-iodopyridin-3-ol (CAS 1207973-15-6)
- N-(3,5-Dichlorophenyl)-3-oxobutanamide (CAS 52793-04-1)
- 3-(Methylnitrosamino)propionitrile (CAS 60153-49-3)
- Tri-o-tolylbismuthine (CAS 10050-08-5)
- 5-Bromo-6-methoxy-4-methylpyridin-3-amine (CAS 1565856-81-6)
- Palmitoyl Hexapeptide-12 TFA salt (CAS 171263-26-6(Free Base))
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com