Phenylbutyrate Impurity 14 CAS 358349-85-6
| CAS No. | 358349-85-6 |
| Molecular Formula | C13H18O2 |
| Molecular Weight | 206.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Phenylbutyrate Impurity 14 (CAS 358349-85-6, C13H18O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system, Phenylbutyrate Impurity 14 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 206.28 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H18O2 |
| Molecular Weight | 206.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
Related Phenylbutyrate Standards
- Ethyl 4-Phenylbutyrate (CAS 10031-93-3)
- Sodium Phenylbutyrate (CAS 1716-12-7)
- Phenylbutyrate EP Impurity A (CAS 2051-95-8)
- Phenylbutyrate Impurity 16 (CAS CATO-C4X-258316)
- Phenylbutyrate Impurity 5 (CAS 1443417-17-1)
- Phenylbutyrate Impurity 6 (CAS 1292210-87-7)
- Phenylbutyrate (Acid) (CAS 1821-12-1)
- Phenylbutyrate Impurity 9 (CAS 54698-75-8)
Recommended Standards
- Prilocaine EP Impurity F (CAS 42459-45-0)
- Ionone Impurity 2 (CAS 29790-29-2)
- Prilocaine Hydrochloride EP Impurity G (CAS 145133-92-2)
- Mirogabalin Impurity 109 (CAS 1644251-48-8)
- Brexpiprazole Impurity 133 (CAS 1268367-99-2)
- Ipragliflozin Impurity 6 (CAS 951382-34-6)
- Fesoterodine Impurity 1 (CAS 250214-44-9)
- 2-((1S,2S)-2-(1H-Imidazol-4-yl)cyclopropyl)ethanamine (CAS 733735-90-5)
- Suvorexant Impurity 9 (CAS 2762965-06-8)
- 2-(2-Heptadecyl-1-(2-stearamidoethyl)-4,5-dihydro-1H-imidazol-1-ium-1-yl)acetate (CAS 65350-78-9)
- 4-Acetyloxy-N-despropyl Ropivacaine (CAS 1797399-64-4)
- 2-(Dichloromethyl)quinazolin-4(3H)-one (CAS 724746-72-9)
- Lumateperone Impurity 38 (CAS CATO-C4X-220138)
- Retatrutide (CAS 2381089-83-2)
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