Macitentan Impurity 19 CAS 36082-50-5
| CAS No. | 36082-50-5 |
| Molecular Formula | C4HBrCl2N2 |
| Molecular Weight | 227.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Macitentan Impurity 19 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Macitentan Impurity 19 (CAS 36082-50-5), a pharmacopoeial impurity reference standard (molecular formula C4HBrCl2N2, MW 227.87 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Macitentan Impurity 19 (C4HBrCl2N2) is characterized by a nitrile group, chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C4HBrCl2N2 |
| Molecular Weight | 227.87 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Macitentan Standards
- Macitentan Impurity 37 (CAS CATO-C4X-117537)
- Macitentan Impurity 11 (CAS 1393813-40-5)
- Macitentan Impurity 28 (CAS 147000-89-3)
- Macitentan Impurity 13 (CAS 3974-18-3)
- Macitentan impurity 51 (CAS CATO-C4X-117551)
- Macitentan impurity 53 (CAS 2211054-46-3)
- Macitentan Impurity 9 (CAS 706811-25-8)
- Macitentan Impurity 8 (CAS 38353-06-9)
Recommended Standards
- 5-Bromo-4,6-dichloropyrimidine (CAS 68797-61-5)
- 2,2-Dibromocyclobutan-1-one (CAS 2885-97-4)
- 4-Bromo-2,6-dichloropyrimidine (CAS 98519-66-5)
- Ilaprazole Impurity 135 (CAS 125131-90-0)
- Parecoxib Impurity 30 (CAS 1373038-57-3)
- Semaglutide Impurity 16 (CAS CATO-C4X-222616)
- Dexmedetomidine Impurity 100 (CAS 79928-28-2)
- 6-Fluoro-4-methyl-3-(1H)indazole carboxylic Acid (CAS 885521-12-0)
- N-(2,6-Dimethylphenyl)-3-methylisoxazole-5-carboxamide (CAS 130403-05-3)
- Sodium Isopropoxide (CAS 683-60-3)
- 2-[(2-Methylpentyl)oxy]-5-(trifluoromethyl)aniline (CAS 946773-14-4)
- 2-(tert-Butylsulfonyl)benzoic acid (CAS 5293-55-0)
- 2-Bromo-6-(4-(pentan-3-yl)-4H-1,2,4-triazol-3-yl)pyridine (CAS 2420428-00-6)
- Tau Peptide (268-282) trifluoroacetate salt (CAS 330456-37-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com