Macitentan Impurity 28 CAS 147000-89-3
| CAS No. | 147000-89-3 |
| Molecular Formula | C5H10ClNO4S |
| Molecular Weight | 215.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Macitentan Impurity 28 (CAS 147000-89-3), a pharmacopoeial impurity reference standard (molecular formula C5H10ClNO4S, MW 215.66 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Macitentan Impurity 28 (C5H10ClNO4S) contains a carbohydrate-derived structure, an amide group, a sulfone group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 1.0, corresponding to approximately 1 ring(s) or double-bond equivalent(s). With a molecular weight of 215.66 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H10ClNO4S |
| Molecular Weight | 215.66 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Macitentan Standards
- Macitentan Impurity 19 (CAS 36082-50-5)
- Macitentan Impurity 37 (CAS CATO-C4X-117537)
- Macitentan Impurity 11 (CAS 1393813-40-5)
- Macitentan Impurity 8 (CAS 38353-06-9)
- Macitentan Impurity 49 (CAS CATO-C4X-117549)
- Macitentan Impurity 13 (CAS 3974-18-3)
- Macitentan Impurity 28 (CAS CATO-C4X-117528)
- Macitentan impurity 51 (CAS CATO-C4X-117551)
Recommended Standards
- 2-chloro-6-methanesulfonylbenzonitrile (CAS 1443981-55-2)
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- 5-((5-Chlorothiophen-2-yl)methyl)-1,3,4-oxadiazol-2-amine (CAS 1706440-50-7)
- Everolimus Impurity 25 (CAS CATO-C4X-112225)
- Cabergoline EP Impurity C (CAS 126554-50-5)
- Crizotinib impurity 23 (CAS 877399-73-0)
- Sofosbuvir impurity 123 (CAS 2875067-01-7)
- 4-(4-Bromophenyl)butan-2-ol (CAS 223554-16-3)
- 4-Benzo[c][1,2,5]oxadiazoleboronic Acid (CAS 207279-32-1)
- 3-(4-Chlorophenyl)-N-(2,4-dichlorophenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide (CAS 320417-84-3)
- Rotigotine EP Impurity H HCl (CAS 1232344-37-4)
- (2-Chlorophenyl)(cyclopentyl)methanol (CAS 19833-92-2)
- Smac-N7 Peptide (CAS 401913-57-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com