Dexmedetomidine Impurity 100 CAS 79928-28-2
| CAS No. | 79928-28-2 |
| Molecular Formula | C13H16N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dexmedetomidine Impurity 100 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Dexmedetomidine Impurity 100 (CAS 79928-28-2, C13H16N2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Dexmedetomidine Impurity 100 is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 236.74 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Dexmedetomidine Impurity 100 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H16N2 HCl |
| Molecular Weight | 236.74 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Dexmedetomidine Standards
- Dexmedetomidine hydrochloride USP Impurity B (CAS 1021949-47-2)
- Dexmedetomidine Impurity 58 (CAS 104175-24-8)
- Dexmedetomidine Impurity 13 (CAS 104245-83-2)
- Dexmedetomidine (CAS 113775-47-6)
- Dexmedetomidine Impurity 51 (CAS 13651-55-3)
- Dexmedetomidine Hydrochloride (CAS 145108-58-3)
- Dexmedetomidine Impurity 28 (CAS 176721-01-0)
- Dexmedetomidine Impurity 29 (CAS 176721-02-1)
Recommended Standards
- Linagliptin impurity 118 (CAS CATO-C4X-1101118)
- Fluocinolone Acetonide EP Impurity L (CAS 1893-65-8)
- Prednisolone impurity 60 (CAS CATO-C4X-173760)
- 1-Phenyl-2-(pyridin-2-yl)ethan-1-one (CAS 1620-53-7)
- 2,2-dimethylpentan-3-amine (CAS 73153-81-8)
- 4-(4-(2-Methoxyphenyl)piperidin-1-yl)-3-nitrobenzaldehyde (CAS 301334-92-9)
- 3-[(3R)-Pyrrolidin-3-yl]-3,4-dihydro-1H-2lambda(6),1,3-benzothiadiazine-2,2-dione hydrochloride (CAS 1389310-02-4)
- Methyl 2-O-allyl-4-6-O-benzylidene-3-O-(2-3-4-6-tetra-O-acetyl-α-D-mannopyranosyl)-α-D-mannopyranoside (CAS 82185-93-1)
- Ethyl benzimidate (CAS 825-60-5)
- Liraglutide (CAS 204656-20-2)
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