Rivaroxaban Impurity 134 CAS 36157-41-2
| CAS No. | 36157-41-2 |
| Molecular Formula | C5H2Cl2O2S |
| Molecular Weight | 197.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Rivaroxaban Impurity 134 (CAS 36157-41-2) is a certified pharmaceutical impurity reference standard with the molecular formula C5H2Cl2O2S and a molecular weight of 197.04 g/mol.
Structurally, Rivaroxaban Impurity 134 (C5H2Cl2O2S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 197.04 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H2Cl2O2S |
| Molecular Weight | 197.04 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Rivaroxaban Standards
- Rivaroxaban Impurity 22 (CAS 31166-29-7)
- Rivaroxaban Impurity 61 (CAS 89166-94-9)
- Rivaroxaban Impurity 96 (CAS 1007650-38-5)
- Rivaroxaban Impurity 97 (CAS 2288308-42-7)
- Rivaroxaban Impurity 87 (CAS 96800-35-0)
- Rivaroxaban impurity 193 (CAS CATO-C4X-1090193)
- Rivaroxaban Impurity 32 (CAS 438056-69-0)
- Rivaroxaban Impurity 47 (CAS 1082588-73-5)
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