Hydrocortisone Impurity 31 CAS 10184-70-0
| CAS No. | 10184-70-0 |
| Molecular Formula | C21H28O4 |
| Molecular Weight | 344.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Hydrocortisone Impurity 31 (C21H28O4) contains a flavonoid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Hydrocortisone Impurity 31 (CAS 10184-70-0, C21H28O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Hydrocortisone Impurity 31 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H28O4 |
| Molecular Weight | 344.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
Related Hydrocortisone Standards
- Hydrocortisone Impurity (CAS 20287-97-2)
- Hydrocortisone (E)-17-Deoxyaldehyde Derivative (CAS 105562-12-7)
- Hydrocortisone (Z)-17-Deoxyaldehyde Derivative (CAS 105562-13-8)
- Hydrocortisone Impurity 68 (CAS 3103-16-0)
- Hydrocortisone EP Impurity L (CAS 641-77-0)
- Hydrocortisone EP Impurity F (CAS 152-58-9)
- Hydrocortisone (9beta,11beta)-Epoxide (CAS 10072-97-6)
- Hydrocortisone EP Impurity A (CAS 50-24-8)
Recommended Standards
- Perindopril EP Impurity B-d4 (CAS 1356841-18-3)
- 620-68-8 Z9J25OS07L Glycerol trivalerate Pentanoic acid, 1,2,3-propanetriyl ester Propane-1,2,3-triyl trivalerate EINECS 210-648-8 UNII-Z9J25OS07L (CAS 620-68-8)
- Propane-1,2,3-triyl tris(3-methylbutanoate) (CAS 620-63-3)
- Lovastatin Impurity 12 (CAS CATO-C4X-168412)
- Tegoprazan Impurity 100 (CAS CATO-C4X-2297100)
- Perampanel Impurity 30 (CAS 1284376-94-8)
- Cefadroxil Impurity 39 (CAS CATO-C4X-122439)
- Isavuconazole Impurity 101 (CAS CATO-C4X-1236101)
- (4-Bromophenyl)(5-chloro-2-methoxyphenyl)methanol (CAS 1280596-23-7)
- Methyl [3,4'-bipyridine]-6-carboxylate (CAS 1214375-04-8)
- Benzylidene 2-fluorenamine (CAS 13924-50-0)
- 1H-1,2,3-Benzotriazole-5-carbonyl chloride (CAS 46053-85-4)
- 1-(Difluoromethyl)quinolin-2(1H)-one (CAS 2341-26-6)
- Des-Ala35-Tirzepatide (CAS CATO-CPTD788939)
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