Penfluridol Impurity N1 CAS 372956-43-9
| CAS No. | 372956-43-9 |
| Molecular Formula | C14H6Cl2F6 |
| Molecular Weight | 359.09 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Penfluridol Impurity N1 is closely related to fluorine/chlorine substitution, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Penfluridol Impurity N1 (CAS 372956-43-9) is a certified pharmaceutical impurity reference standard with the molecular formula C14H6Cl2F6 and a molecular weight of 359.09 g/mol.
The molecular framework of Penfluridol Impurity N1 (C14H6Cl2F6) is characterized by fluorine/chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H6Cl2F6 |
| Molecular Weight | 359.09 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
Related Penfluridol Standards
- Penfluridol Impurity 3 (CAS CATO-C4X-35383)
- Penfluridol Impurity 4 (CAS CATO-C4X-35384)
- Penfluridol Impurity 6 (CAS CATO-C4X-35386)
- Penfluridol Impurity 15 (CAS 94545-16-1)
- Penfluridol Impurity 1 (CAS 21928-50-7)
- Penfluridol Impurity 8 (CAS 77294-14-5)
- Penfluridol Impurity 11 (CAS CATO-C4X-353811)
- Penfluridol Impurity 10 (CAS 262272-58-2)
Recommended Standards
- 5,5'-Bis-Trifluoromethyl-2,2'-Dichlorobiphenyl (CAS 99686-52-9)
- Afoxolaner Impurity 12 (CAS CATO-C4X-313712)
- 4-Cyano-2-(difluoromethyl)-6-iodopyridine-3-sulfonamide (CAS 1806952-82-8)
- 2,6-Difluoro-N-(4-iodophenyl)benzamide (CAS 418801-29-3)
- Bempedoic Acid Impurity 13 (CAS 738606-43-4)
- Ritonavir Impurity N11 (CAS 2519851-81-9)
- Tioconazole EP Impurity C (CAS 119386-76-4)
- 4-Oxazolecarbonitrile, 2-phenyl- (CAS 55613-13-3)
- 2-Chloro-3-nitropyrazine (CAS 87885-43-6)
- Ethyl 5-(1,4-dioxan-2-yl)-1,2,4-oxadiazole-3-carboxylate (CAS 1343828-40-9)
- Methyl 3-(4-chloro-3-nitro-1h-pyrazol-1-yl)propanoate (CAS 1006993-44-7)
- N-[(4-formylphenyl)methyl]acetamide (CAS 156866-50-1)
- 2-(Phenylsulfonyl)-1-(5-(phenylsulfonyl)furan-2-yl)ethanone (CAS 853334-11-9)
- C-Peptide 1 (rat) (CAS 41475-27-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com