Afoxolaner Impurity 12 CAS CATO-C4X-313712
| CAS No. | CATO-C4X-313712 |
| Molecular Formula | C14H6Cl2F6 |
| Molecular Weight | 359.09 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Afoxolaner Impurity 12.
As a process- or degradation-related impurity, Afoxolaner Impurity 12 (CAS CATO-C4X-313712, C14H6Cl2F6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Afoxolaner Impurity 12 (C14H6Cl2F6) contains fluorine/chlorine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 359.09 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Afoxolaner Impurity 12 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H6Cl2F6 |
| Molecular Weight | 359.09 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
Related Afoxolaner Standards
- Afoxolaner Impurity 1 (CAS 1125812-54-5)
- Afoxolaner impurity 3 (CAS CATO-C4X-31373)
- Afoxolaner impurity 11 (CAS CATO-C4X-31381)
- Afoxolaner Impurity 33 (CAS CATO-C4X-313733)
- Afoxolaner Impurity 10 (CAS CATO-C4X-313710)
- Afoxolaner Impurity 16 (CAS 1190862-76-0)
- Afoxolaner impurity 6 (CAS CATO-C4X-31376)
- Afoxolaner Impurity 18 (CAS CATO-C4X-313718)
Recommended Standards
- Penfluridol Impurity N1 (CAS 372956-43-9)
- 2,6-Difluoro-N-(4-iodophenyl)benzamide (CAS 418801-29-3)
- 5,5'-Bis-Trifluoromethyl-2,2'-Dichlorobiphenyl (CAS 99686-52-9)
- 2-Fluoro-N-(2-fluoro-4-iodophenyl)benzamide (CAS 842117-78-6)
- Rivaroxaban Impurity 78 (CAS CATO-C4X-109078)
- Dexamethasone Impurity 113 (CAS CATO-C4X-1165113)
- Famotidine Impurity C22 (CAS 86794-42-5)
- 3-(3-Fluoro-4-(trifluoromethyl)phenyl)propanoic acid (CAS 916420-40-1)
- N-Benzyl-1-(2-ethyl-5-methylfuran-3-yl)methanamine (CAS 777040-81-0)
- 4-Amino-1-methyl-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (CAS 71703-04-3)
- 3-(5-Methyl-1H-indazol-3-yl)propanoic acid (CAS 1522868-92-3)
- 1-tert-butyl 2-methyl 2-(2-oxoethyl)azetidine-1,2-dicarboxylate (CAS 1148044-27-2)
- 4-chloro-N-[2-(dimethylamino)ethyl]-3-nitrobenzenesulfonamide (CAS 790263-62-6)
- Semaglutide impurity 86 (CAS CATO-C4X-222686)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com