Tadalafil Impurity 156 CAS 378788-16-0
| CAS No. | 378788-16-0 |
| Molecular Formula | C22H21N3O4 |
| Molecular Weight | 391.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Tadalafil Impurity 156 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Tadalafil Impurity 156 (CAS 378788-16-0), a pharmacopoeial impurity reference standard (molecular formula C22H21N3O4, MW 391.42 g/mol) used for the identification and quantification of trace impurities in APIs.
Tadalafil Impurity 156 (C22H21N3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H21N3O4 |
| Molecular Weight | 391.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 3 |
Related Tadalafil Standards
Recommended Standards
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- Tirofiban Impurity 124 (CAS CATO-C4X-1254124)
- [3-(trifluoromethyl)-1,2-oxazol-4-yl]methanol (CAS 493019-55-9)
- 4,6-Dichloroisobenzofuran-1,3-dione (CAS 51971-64-3)
- 4-((4-Nitrophenyl)diazenyl)benzene-1,2-diol (CAS 843-33-4)
- 4-(tert-Butyl)3-methyl6,6-dimethylmorpholine-3,4-dicarboxylate (CAS 1272758-01-6)
- Semaglutide impurity 44 (CAS CATO-C4X-222644)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com