Perampanel Impurity 1 CAS 381248-06-2
| CAS No. | 381248-06-2 |
| Molecular Formula | C16H11BrN2O |
| Molecular Weight | 327.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Perampanel Impurity 1 (CAS 381248-06-2, C16H11BrN2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Perampanel Impurity 1 (C16H11BrN2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C16H11BrN2O |
| Molecular Weight | 327.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Perampanel Standards
- Perampanel Impurity 44 (CAS CATO-C4X-243044)
- Perampanel Impurity 45 (CAS CATO-C4X-243045)
- Perampanel impurity 48 (CAS CATO-C4X-243048)
- Perampanel Impurity 9 (CAS 380918-51-4)
- Perampanel Impurity 31 (CAS CATO-C4X-243031)
- Perampanel Impurity 20 (CAS 2137956-02-4)
- Perampanel Impurity 33 (CAS CATO-C4X-243033)
- Perampanel Impurity 46 (CAS CATO-C4X-243046)
Recommended Standards
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- N-(4,5-Dichlorobenzo[d]thiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxamide (CAS 1170084-48-6)
- Alfacalcidol Impurity 26 (CAS CATO-C4X-139326)
- Landiolol Impurity 84 HCl (CAS CATO-C4X-262184)
- Agomelatine Impurity 34 (CAS 27533-69-3)
- 4-Chloro-6-(difluoromethyl)-2-iodo-3-methylpyridine (CAS 1806935-11-4)
- 4-Hydroxy Phenobarbital (CAS 379-34-0)
- 5-Hydroxy-3,3-dimethylcyclohexanecarboxylic acid (CAS 1363405-98-4)
- 3,5-Diethyl 1-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-pyrazole-3,5-dicarboxylate (CAS 1638612-94-8)
- 3-amino-1-[(oxolan-2-yl)methyl]urea (CAS 1094481-42-1)
- 4,6-Dichloroindoline hydrochloride (CAS 1210734-76-1)
- Neuropeptide Y (2-36), amide, porcine (CAS 102961-52-4)
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