Tenofovir alafenamide Impurity 17 CAS 382140-25-2(Free Base)

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.382140-25-2(Free Base)
Molecular FormulaC20H27N6O5P
Molecular WeightN/A
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Tenofovir alafenamide Impurity 17 CAS 382140-25-2(Free Base) chemical structure

Description

Compared with other compounds in its class, the molecular weight of 578.52 g/mol gives Tenofovir alafenamide Impurity 17 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Tenofovir alafenamide Impurity 17 (CAS 382140-25-2(Free Base)) is a certified pharmaceutical impurity reference standard with the molecular formula C20H27N6O5PC4H4O4 and a molecular weight of 578.52 g/mol.

Structurally, Tenofovir alafenamide Impurity 17 (C20H27N6O5PC4H4O4) contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 12.5, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 578.52 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC20H27N6O5P C4H4O4
Molecular Weight578.52 g/mol
AppearancePale yellow to yellow crystalline powder
Purity>95%
StorageStore in a cool place (≤25°C), protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening
Degree of Unsaturation (DBE)12.5
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
Nitrogen Atoms6

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