Resmetirom impurity 131 CAS 2768216-97-1
| CAS No. | 2768216-97-1 |
| Molecular Formula | C13H11Cl2N3O4 |
| Molecular Weight | 344.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 344.15 g/mol gives Resmetirom impurity 131 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Resmetirom impurity 131 (CAS 2768216-97-1) is a certified pharmaceutical impurity reference standard with the molecular formula C13H11Cl2N3O4 and a molecular weight of 344.15 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Resmetirom impurity 131 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 344.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Resmetirom impurity 131 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H11Cl2N3O4 |
| Molecular Weight | 344.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Resmetirom Standards
- Resmetirom impurity 82 (CAS CATO-C4X-291282)
- Resmetirom Impurity 100 (CAS CATO-C4X-2912100)
- Resmetirom Impurity 127 (CAS CATO-C4X-2912127)
- Resmetirom Impurity 48 (CAS CATO-C4X-291248)
- Resmetirom Impurity 102 (CAS CATO-C4X-2912102)
- Resmetirom impurity 103 (CAS CATO-C4X-2912103)
- Resmetirom Impurity 30 (CAS CATO-C4X-291230)
- Resmetirom Impurity 5 (CAS 920509-27-9)
Recommended Standards
- Metronidazole Impurity 27 (CAS CATO-C4X-140527)
- Tert-butyl 5-iodo-1H-benzo[d]imidazole-1-carboxylate (CAS 705262-62-0)
- 5-Benzoyl-2-(4-bromophenyl)-1H-1,2,4-triazol-3(2H)-one (CAS 1000574-42-4)
- tert-Butyl 3-iodo-1H-pyrrolo[3,2-c]pyridine-1-carboxylate (CAS 877060-48-5)
- Papaverine Impurity 27 (CAS 855737-36-9)
- Baloxavir Impurity 42 (CAS 2365473-17-0)
- Urapidil Impurity 107 (CAS CATO-C4X-1924107)
- 2-Iodo-4-(methoxycarbonyl)benzoic acid (CAS 1822764-03-3)
- Loxoprofen Impurity 140 (CAS CATO-C4X-1488140)
- 1-Azabicyclo[2.2.1]heptane-4-carboxylic acid hydrobromide (CAS 130513-74-5)
- 1-Ethanesulfonyl-3-fluorobenzene (CAS 1020734-47-7)
- 4,4'-Bis(dimethylsilyl)-1,1'-biphenyl (CAS 17937-85-8)
- 1-Amino-3-(4-methyl-1h-pyrazol-1-yl)cyclohexane-1-carboxylic acid (CAS 1512319-91-3)
- Neuropeptide S (rat) (CAS 412938-75-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com