Tenofovir Alafenamide Impurity 16 CAS 390409-27-5
| CAS No. | 390409-27-5 |
| Molecular Formula | C19H25N6O5P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tenofovir Alafenamide Impurity 16 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Tenofovir Alafenamide Impurity 16 (CAS 390409-27-5) is a certified pharmaceutical impurity reference standard with the molecular formula C19H25N6O5PC4H4O4 and a molecular weight of 564.49 g/mol.
Structurally, Tenofovir Alafenamide Impurity 16 (C19H25N6O5PC4H4O4) contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 12.5, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 564.49 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C19H25N6O5P C4H4O4 |
| Molecular Weight | 564.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 6 |
Related Tenofovir Standards
- Tenofovir alafenamide Impurity 79 (CAS 102-10-3)
- rac Tenofovir-d6 (CAS 1020719-94-1)
- Tenofovir disoproxil Impurity 142 (CAS 102537-97-3)
- Tenofovir Disoproxil Dimer (CAS 1093279-76-5)
- Tenofovir disoproxil Impurity 6 (CAS 1093279-77-6)
- Tenofovir disoproxil Impurity 28 (CAS 1115-59-9)
- Tenofovir Impurity 59 (CAS 116384-56-6)
- Tenofovir alafenamide impurity 85 (CAS 121149-98-2)
Recommended Standards
- Norepinephrine Impurity 65 (CAS CATO-C4X-151465)
- Ursodeoxycholic acid impurity 54 (CAS 57011-24-2)
- Latamoxef impurity 41 (CAS CATO-C4X-179841)
- 1-amino-3-bromopyridin-1-ium 2,4,6-trimethylbenzene-1-sulfonate (CAS 55899-13-3)
- 5-Fluoro-3-methyl-2-nitropyridine (CAS 1211541-84-2)
- Entacapone Impurity 60 (CAS CATO-C4X-162960)
- Sodium 3-((6-chloro-2-cyclopropyl-1-(1-ethyl-1H-pyrazol-4-yl)-7-fluoro-1H-indol-3-yl)thio)-2-fluorobenzoate (CAS 1782070-85-2)
- 4-(2-Fluoro-3-methoxyphenyl)pyridine (CAS 1214333-86-4)
- [3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl N3-Acetylpenicilloic Acid (CAS 934986-84-2)
- (Thr(PO3H2)231)-Tau Peptide (225-237) trifluoroacetate salt (CAS 1670270-09-3)
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