Tenofovir alafenamide Impurity 61 CAS 390409-48-0
| CAS No. | 390409-48-0 |
| Molecular Formula | C20H27N6O5P |
| Molecular Weight | 462.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Tenofovir alafenamide Impurity 61 (CAS 390409-48-0, C20H27N6O5P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Tenofovir alafenamide Impurity 61 (C20H27N6O5P) contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H27N6O5P |
| Molecular Weight | 462.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 6 |
Related Tenofovir Standards
- Tenofovir Alafenamide Impurity 50 (CAS 1878175-77-9)
- Tenofovir disoproxil Impurity 141 (CAS CATO-C4X-1076141)
- Tenofovir alafenamide Impurity 16 Free base (CAS CATO-C4X-179769)
- Tenofovir alafenamide impurity 73 (CAS CATO-C4X-179773)
- Tenofovir alafenamide Impurity 95 (CAS CATO-C4X-179795)
- Tenofovir alafenamide Impurity 33 (CAS CATO-C4X-179733)
- Tenofovir alafenamide Impurity 42 (CAS 2053424-82-9)
- Tenofovir alafenamide Impurity 44 (CAS CATO-C4X-179744)
Recommended Standards
- {4-[(4-methylphenyl)sulfanyl]-3-nitrophenyl}methyl N-[3-(trifluoromethyl)phenyl]carbamate (CAS 320424-09-7)
- Difamilast Impurity 2 (CAS 2103190-94-7)
- Raltegravir EP Impurity C (CAS 1391918-17-4)
- Difamilast Impurity 4 (CAS 2103190-65-2)
- CMC2026 Impurity 4 (CAS CATO-C4X-22664)
- Abrocitinib Impurity 45 (CAS CATO-C4X-288445)
- Menaquinone impurity 31 (CAS CATO-C4X-207631)
- 3-(6-methylpyridine-3-carbonyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine (CAS 1803610-67-4)
- 5-Amino-2-(benzyloxy)benzonitrile (CAS 848134-18-9)
- 2-Bromo-6-(1-fluoro-2-methylpropan-2-yl)pyridine (CAS 2506347-62-0)
- 1181778-98-2 1-(4-Ethoxyphenyl)-2,5-dimethyl-1H-pyrrole-3-carbonitrile MFCD11919759 (CAS 1181778-98-2)
- 3-(4-Bromo-2-isopropylphenoxy)piperidinehydrochloride (CAS 1220032-71-2)
- 2,2-Difluoro-N-methylethanamine (CAS 60168-06-1)
- [α-Glu](Side Chain)-Semaglutide (CAS CATO-C4X-2226159)
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