Fluocinolone Acetonide Impurity 32 CAS 3914-23-6
| CAS No. | 3914-23-6 |
| Molecular Formula | C25H30F2O8 |
| Molecular Weight | 496.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution, Fluocinolone Acetonide Impurity 32 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 496.50 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Fluocinolone Acetonide Impurity 32 (CAS 3914-23-6, C25H30F2O8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Fluocinolone Acetonide Impurity 32 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H30F2O8 |
| Molecular Weight | 496.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F-containing |
Related Fluocinolone Standards
- Fluocinolone Acetonide Impurity 23 (CAS CATO-C4X-238123)
- Fluocinolone Acetonide Impurity 27 (CAS 3932-49-8)
- Fluocinolone Acetonide Impurity 36 (CAS CATO-C4X-238136)
- Fluocinolone Acetonide EP Impurity M (CAS 356-12-7)
- Fluocinolone Acetonide Impurity 24 (CAS CATO-C4X-238124)
- Fluocinolone Acetonide Impurity 4 (CAS 62013-83-6)
- Fluocinolone Acetonide Impurity 37 (CAS CATO-C4X-238137)
- Fluocinolone Acetonide Impurity 15 (CAS 1181-32-4)
Recommended Standards
- 6,8-Dibromo-3-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methylquinoline (CAS 861210-77-7)
- H-Tyr-Glu-Trp-OH (CAS 122409-30-7)
- Zearalenone Impurity 4 (CAS 312305-41-2)
- Dimethyl2'-hydroxy-5'-(4-(methoxycarbonyl)phenyl)-[1,1':3',1''-terphenyl]-4,4''-dicarboxylate (CAS 1353118-72-5)
- Faropenem Impurity 53 (CAS CATO-C4X-128953)
- Rupatadine impurity 47 (CAS CATO-C4X-102747)
- Acotiamide Impurity 31 (CAS CATO-C4X-111431)
- [2-(trifluoromethyl)pyridin-4-yl]boronic acid (CAS 1093407-58-9)
- Clopidogrel Impurity 13 (CAS 141109-14-0)
- Methyl 2-(3,4-dichlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylate (CAS 164667-44-1)
- 1-[4-(3-methoxyphenyl)-6-(trifluoromethyl)pyrimidin-2-yl]piperidine-3-carboxylic acid (CAS 870980-07-7)
- 5-(Difluoromethyl)-2-methyl-1,3-thiazole-4-carbonyl chloride (CAS 685565-98-4)
- 1-methyl-3-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid (CAS 1152510-52-5)
- Peptide T (CAS 106362-32-7)
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