Levothyroxine Impurity 14 CAS 3914-31-6
| CAS No. | 3914-31-6 |
| Molecular Formula | C15H11I3O4 |
| Molecular Weight | 635.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 635.96 g/mol gives Levothyroxine Impurity 14 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Levothyroxine Impurity 14 (CAS 3914-31-6), a pharmacopoeial impurity reference standard (molecular formula C15H11I3O4, MW 635.96 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Levothyroxine Impurity 14 (C15H11I3O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H11I3O4 |
| Molecular Weight | 635.96 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | I-containing |
Related Levothyroxine Standards
- Levothyroxine Impurity 17 (CAS 51-26-3)
- Levothyroxine EP Impurity C (CAS 51-24-1)
- Levothyroxine Impurity 16 (CAS 92905-78-7)
- Levothyroxine EP Impurity A (CAS 6893-02-3)
- Levothyroxine EP Impurity K (CAS 5817-39-0)
- Levothyroxine EP Impurity K (R-Isomer) (CAS 66701-15-3)
- Levothyroxine Impurity 42 (CAS 4618-45-5)
- Levothyroxine Impurity 15 (CAS CATO-C4X-167815)
Recommended Standards
- N-[1-(Cyclohexylmethyl)-4-piperidinyl]-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine (CAS 1320288-19-4)
- C26:0 Lyso PC (CAS 1213783-80-2)
- delafloxacin Impurity 5 (CAS CATO-C4X-26375)
- Resmetirom impurity 119 (CAS CATO-C4X-2912119)
- ZHC-116 Impurity D (CAS CATO-C4X-23881)
- Milrinone Impurity 6 (CAS 1443528-66-2)
- Timolol EP Impurity C Maleate (CAS 610271-57-3)
- 6-Bromo-4-(difluoromethyl)-5-hydroxypicolinonitrile (CAS 1805009-85-1)
- n-(2-Fluorophenyl)-2-(2-(hydrazinecarbonyl)phenoxy)acetamide (CAS 554404-41-0)
- 4-Chloro-3-((4-chlorophenyl)sulfonyl)-2-methyl-1H-indole (CAS 646514-81-0)
- 1,7-Dimethyl-1H-purin-6(7H)-one (CAS 33155-83-8)
- 1-(3-Piperidinyl)indoline dihydrochloride (CAS 1219957-54-6)
- 2-Methyl-1-(4-propylphenyl)propan-1-one (CAS 116706-95-7)
- Tirzepatide Impurity 58 (CAS CATO-C4X-324058)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com