Empagliflozin impurity 253 CAS 395-11-9
| CAS No. | 395-11-9 |
| Molecular Formula | C13H8FIO |
| Molecular Weight | 326.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Empagliflozin impurity 253 (CAS 395-11-9, C13H8FIO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Empagliflozin impurity 253 (C13H8FIO) contains a hydroxyl group, an ether linkage, fluorine/iodine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Empagliflozin impurity 253 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H8FIO |
| Molecular Weight | 326.10 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/I-containing |
Related Empagliflozin Standards
- Empagliflozin impurity 262 (CAS CATO-C4X-1065262)
- Empagliflozin Impurity 135 (CAS 2760767-62-0)
- Empagliflozin impurity 215 (CAS 2452301-37-8)
- Empagliflozin impurity (CAS CATO-C4X-1065179)
- Empagliflozin impurity 202 (CAS CATO-C4X-1065202)
- Empagliflozin impurity 229 (CAS CATO-C4X-1065229)
- Empagliflozin Impurity 155 (CAS CATO-C4X-1065155)
- Empagliflozin Impurity 147 (CAS 501009-13-8)
Recommended Standards
- Diethyl ((6-bromopyridin-2-yl)fluoromethyl)phosphonate (CAS 2416421-43-5)
- 6,8-Dichloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide (CAS 1177415-97-2)
- 4-[(4-bromo-3-nitro-1h-pyrazol-1-yl)methyl]benzoic acid (CAS 514800-72-7)
- (5-Bromofuran-2-yl)(3-(trifluoromethyl)piperidin-1-yl)methanone (CAS 1197784-52-3)
- Empagliflozin Impurity 1 (CAS 864070-43-9)
- Docetaxel Impurity 46 (CAS 158810-72-1)
- Pivampicillin EP Impurity A (CAS CATO-C4X-23221)
- 2-Methyl-1-(5-methyl-1h-1,2,4-triazol-3-yl)butan-1-amine (CAS 1249103-73-8)
- Methyl (1S,2R,4R)-7-oxabicyclo[2.2.1]Heptane-2-carboxylate (CAS 937053-08-2)
- N-(1-Ethyl-2-(furan-2-yl)-3-methyl-4-oxoazetidin-3-yl)benzamide (CAS 91815-07-5)
- 2-(3-Amino-4-methylpyridin-2-yl)propan-2-ol (CAS 2407073-26-9)
- Isavuconazole impurity 163 (CAS CATO-C4X-1236163)
- Methyl 2-(3-chlorophenyl)-4-oxo-4-phenylbutanoate (CAS 344280-08-6)
- Insulin Glargine Metabolite M2 (CAS CATO-CPTD788867)
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