Trazodone Impurity N16 CAS 39577-43-0
| CAS No. | 39577-43-0 |
| Molecular Formula | C13H18Cl2N2 |
| Molecular Weight | 273.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Trazodone Impurity N16 (CAS 39577-43-0, C13H18Cl2N2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Trazodone Impurity N16 (C13H18Cl2N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H18Cl2N2 |
| Molecular Weight | 273.20 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Trazodone Standards
- Trazodone impurity 54 (CAS CATO-C4X-177254)
- Trazodone Impurity 66 (CAS CATO-C4X-177266)
- Trazodone Impurity 73 (CAS 6323-14-4)
- Trazodone Impurity 89 (CAS CATO-C4X-177289)
- Trazodone Impurity 103 (CAS CATO-C4X-1772103)
- Trazodone Impurity 36 (CAS CATO-C4X-177236)
- Trazodone impurity 77 (CAS 1799917-53-5)
- Trazodone impurity 64 (CAS CATO-C4X-177264)
Recommended Standards
- 3-bromobenzophenone (CAS 1016-77-9)
- 2-((4-(Trifluoromethyl)phenyl)carbamoyl)cyclopropane-1-carboxylic acid (CAS 1022750-01-1)
- 1-(4-Trifluoromethylphenylcarbamoyl)cyclopropanecarboxylic acid (CAS 113136-89-3)
- Methyl 3,3,3-trifluoro-2-hydroxy-2-(1H-indol-3-yl)propanoate (CAS 114125-58-5)
- Etodolac EP Impurity J (CAS 115066-03-0)
- Regorafenib Impurity 23 (CAS CATO-C4X-104723)
- Celecoxib Impurity 13 (CAS 1576-43-8)
- 1,1'-(5-(Trifluoromethyl)-1,3-phenylene)bis(1H-imidazole) (CAS 2110472-44-9)
- Cefdinir Impurity 71 (CAS CATO-C4X-121071)
- Methyl({[3-(trifluoromethoxy)phenyl]methyl})amine hydrochloride (CAS 1384813-94-8)
- 3-Fluoro-4-propoxybenzenethiol (CAS 1378657-34-1)
- 3-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-4-carbonitrile (CAS 111234-77-6)
- (2-Ethyl-5-fluoro-4-methoxybenzene)boronic acid pinacol ester, 97% (CAS 1421503-46-9)
- Insulin Degludec Impurity 15 (CAS CATO-C4X-215715)
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