Regorafenib Impurity 23 CAS CATO-C4X-104723
| CAS No. | CATO-C4X-104723 |
| Molecular Formula | C16H16FN3O4 |
| Molecular Weight | 333.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Regorafenib Impurity 23 (CAS CATO-C4X-104723, C16H16FN3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Regorafenib Impurity 23 (C16H16FN3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 333.31 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Regorafenib Impurity 23 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H16FN3O4 |
| Molecular Weight | 333.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Regorafenib Standards
- Regorafenib Impurity 83 (CAS CATO-C4X-104783)
- Regorafenib Impurity N2 (CAS 1333390-56-9)
- Regorafenib Impurity 18 (CAS CATO-C4X-104718)
- Regorafenib Impurity 37 (CAS CATO-C4X-104737)
- Regorafenib Impurity 45 (CAS CATO-C4X-104745)
- Regorafenib Impurity 82 (CAS CATO-C4X-104782)
- Regorafenib Impurity 81 (CAS CATO-C4X-104781)
- Regorafenib EP Impurity B (CAS 2141961-84-2)
Recommended Standards
- N-(m-tolyl)-2-(2-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)acetamide (CAS 478030-71-6)
- Retigabine impurity 13 (CAS CATO-C4X-13153)
- N-(4-Methylphenyl)-2-[2-(trifluoromethyl)-1H-1,3-benzodiazol-1-yl]acetamide (CAS 478030-70-5)
- Norfloxacin Impurity 19 (CAS 74011-42-0)
- Naproxen Impurity 46 (CAS 111198-00-6)
- Zopiclone Impurity 12 (CAS CATO-C4X-123812)
- Bilastine impurity 95 (CAS CATO-C4X-225395)
- Triton X-100 (CAS 9002-93-1)
- 3-Bromopyrazolo[1,5-a]pyridin-2(1H)-one (CAS 60637-30-1)
- 3,3’-Oxybis(1-propanol) (CAS 2396-61-4)
- Ethyl({[4-(4-methoxypiperidin-1-yl)phenyl]methyl})amine (CAS 1096865-58-5)
- {4-[(1-methyl-1H-imidazol-2-yl)methoxy]phenyl}methanol (CAS 1094451-64-5)
- 4-Chloro-2-[chloro(difluoro)-methoxy]-1-fluoro-benzene (CAS 1404193-68-5)
- Pancreatic Polypeptide (rat) (CAS 90419-12-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com