Tryptophan EP Impurity E CAS 3978-11-8
| CAS No. | 3978-11-8 |
| Molecular Formula | C11H12N2O4 |
| Molecular Weight | 236.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tryptophan EP Impurity E is closely related to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Tryptophan EP Impurity E (CAS 3978-11-8, C11H12N2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tryptophan EP Impurity E (C11H12N2O4) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H12N2O4 |
| Molecular Weight | 236.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 2 |
Related Tryptophan Standards
- Tryptophan Impurity 7 (CAS 13081-15-7)
- Tryptophan Impurity 16 (CAS CATO-C4X-137316)
- Tryptophan EP Impurity B (Mixture of Diastereomers) (CAS 184955-21-3)
- Tryptophan impurity 38 (Mixture of Diastereomers) (CAS CATO-C4X-137338)
- Tryptophan Impurity 44 (CAS 101948-12-3)
- Tryptophan Impurity 18 (CAS 25198-03-2)
- Tryptophan Impurity 14 (CAS 33468-35-8)
- Tryptophan Impurity 21 (CAS 55325-48-9)
Recommended Standards
- Aspirin Impurity 15 (CAS 61414-18-4)
- Butylphthalide Impurity 32 (CAS 33704-16-4)
- Niraparib Impurity 1 (CAS CATO-C4X-23291)
- Niraparib Impurity 34 (CAS CATO-C4X-232934)
- Colchicine EP Impurity D (CAS 477-29-2)
- Tegoprazan Impurity 4 (CAS CATO-C4X-22974)
- Coclaurine Impurity 1 (CAS 4078-65-3)
- 3,5-Dihydroxy-N-(4-hydroxyphenyl)benzamide (CAS 926294-00-0)
- 6'-Bromo-8'-chloro-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione (CAS 1849592-11-5)
- 3,5-Diacetyl-1,4-Dihydro-2,6-Lutidine (CAS 1079-95-4)
- 2-Bromo-1-(3,4-dichlorophenoxy)-4-nitrobenzene (CAS 477870-28-3)
- Methyl 4-methyl-2-(methylthio)pyrimidine-5-carboxylate (CAS 166392-24-1)
- Benzo[d][1,3]dioxol-5-yl(p-tolyl)methanone (CAS 109365-37-9)
- Des-[Gly]31-Semaglutide (CAS CATO-C4X-2226156)
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