Sitagliptin Impurity 127 CAS CATO-C4X-1144127
| CAS No. | CATO-C4X-1144127 |
| Molecular Formula | C11H16O5 |
| Molecular Weight | 228.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Sitagliptin Impurity 127 (CAS CATO-C4X-1144127) is a certified pharmaceutical impurity reference standard with the molecular formula C11H16O5 and a molecular weight of 228.24 g/mol.
Sitagliptin Impurity 127 (C11H16O5) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H16O5 |
| Molecular Weight | 228.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Sitagliptin Standards
- Sitagliptin Impurity 59 (CAS CATO-C4X-114459)
- Sitagliptin Impurity 78-d4 (CAS 2892260-32-9 (unlabelled))
- Sitagliptin Impurity 61 (CAS 1256815-03-8)
- Sitagliptin Impurity 58 (CAS 667-35-6)
- Sitagliptin Impurity 72 (CAS 1217854-08-4)
- Sitagliptin Impurity 138 (CAS 1283583-85-6)
- Sitagliptin Impurity 33 (CAS 936630-57-8)
- Sitagliptin Impurity 78 (Nitroso-STG-19) (NTTP) (CAS 2892260-32-9)
Recommended Standards
- Ipriflavone Impurity 1 (CAS 3669-41-8)
- Posaconazole Impurity 81 (CAS 165115-73-1)
- Ibrutinib Impurity 79 (CAS 21218-94-0)
- Bisoprolol Impurity 117 (CAS 853233-62-2)
- Oseltamivir impurity 266 (CAS 2762080-42-0)
- Drospirenone EP Impurity D (CAS 67372-69-4)
- Carfilzomib Impurity 57 (CAS CATO-C4X-102257)
- 3-Ethyl 2-methyl 6-hydroxy-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate (CAS 134388-88-8)
- 7,10-Dibenzyl-2,7,10-triazaspiro[4.6]undecane (CAS 1330765-96-2)
- 3-(Piperidin-1-ylmethyl)-1,2,4-thiadiazol-5-amine (CAS 1352999-69-9)
- Isovanillin-2,5,6-d<SUB>3</SUB> (CAS 1173018-82-0)
- 2-(4-Fluorophenyl)sulfanylbenzoic acid (CAS 13420-72-9)
- 1-Methyl-1H-1,2,4-triazole-3-carbonitrile (CAS 1142927-05-6)
- Polymyxin B nonapeptide (CAS 86408-36-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com