2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N'-[(2E)-3-oxobutan-2-ylidene]acetohydrazide CAS 400084-53-9
| CAS No. | 400084-53-9 |
| Molecular Formula | C12H11ClF3N3O2 |
| Molecular Weight | 321.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO supplies 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N'-[(2E)-3-oxobutan-2-ylidene]acetohydrazide (CAS 400084-53-9), a certified reference material (molecular formula C12H11ClF3N3O2, MW 321.68 g/mol) for analytical method development and quality control.
The molecular framework of 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N'-[(2E)-3-oxobutan-2-ylidene]acetohydrazide (C12H11ClF3N3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H11ClF3N3O2 |
| Molecular Weight | 321.68 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- Methyl 5-chloro-2-{[(E)-4,4,4-trifluoro-1-methyl-3-oxo-1-butenyl]amino}benzenecarboxylate (CAS 1210908-67-0)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indole-5-carbonitrile (CAS 151387-94-9)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indole-3-carbonitrile (CAS 151388-01-1)
- (2Z)-1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-2-(ethoxymethylidene)butane-1,3-dione (CAS 900014-69-9)
- 1-(5-(((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-4,5-dihydroisoxazol-3-yl)ethan-1-one (CAS 338422-57-4)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-3-[(1E)-(methoxyimino)methyl]pyrrolidin-2-one (CAS 866051-42-5)
- 3-Chloro-2-(5-(dimethoxymethyl)-1H-pyrazol-1-yl)-5-(trifluoromethyl)pyridine (CAS 318958-91-7)
- 4-(8-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)benzonitrile (CAS 1980053-72-2)
Recommended Standards
- 2-(4-Chlorophenyl)-3-(trifluoromethyl)benzofuran-5-carbonitrile (CAS 821770-06-3)
- N-[4-Amino-2-chloro-6-[(2-deoxy-2-fluoro-alpha-D-arabinopyranosyl)amino]-5-pyrimidinyl]-formamide (CAS 1140251-30-4)
- (R)-3-(2,2,2-Trifluoroacetamido)-2,3-dihydro-1H-inden-5-yl 2-chloroacetate (CAS 209394-88-7)
- 2-Chloro-6-fluoro-N-(5-(1-methyl-1H-pyrazol-5-yl)-1,3,4-oxadiazol-2-yl)benzamide (CAS 1172551-45-9)
- tert-Butyl 4-(2-fluorophenoxy)piperidine-1-carboxylate (CAS 944808-08-6)
- N-Fmoc-N-(3-phenylpropyl)glycine (CAS 2231812-73-8)
- Foeniculin (CAS 78259-41-3)
- tert-Butyl (2R,3R)-2-(hydroxymethyl)-3-(trifluoromethyl)azetidine-1-carboxylate (CAS 2810050-48-5)
- N,N'-(bicyclo[1.1.1]Pentane-1,3-diyl)diacetamide (CAS 2231676-53-0)
- 1,6-Dimethyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid (CAS 33821-59-9)
- 2-(Cyclohexylamino)isonicotinonitrile (CAS 127680-82-4)
- 1,4-Dichloro-2,5-difluorobenzene (CAS 400-05-5)
- N,N'-(9-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purine-2,6-diyl)bis(2-phenoxyacetamide) (CAS 156549-47-2)
- (Met(O)2?)-Glucagon (1-29) (human, rat, porcine) (CAS 75217-63-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com