Estradiol Impurity N1 CAS 4011-48-7
| CAS No. | 4011-48-7 |
| Molecular Formula | C19H24O2 |
| Molecular Weight | 284.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Estradiol Impurity N1 (CAS 4011-48-7), a pharmacopoeial impurity reference standard (molecular formula C19H24O2, MW 284.39 g/mol) used for the identification and quantification of trace impurities in APIs.
Estradiol Impurity N1 (C19H24O2) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H24O2 |
| Molecular Weight | 284.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Estradiol Standards
- Estradiol Impurity 26 (CAS CATO-C4X-163626)
- Estradiol Impurity 27 (CAS CATO-C4X-163627)
- Estradiol Impurity 30 (CAS 4954-08-9)
- Estradiol Impurity 44 (CAS CATO-C4X-163644)
- Estradiol Impurity 51 (CAS 165609-57-4)
- Estradiol Impurity 5 (CAS 1476-34-2)
- Estradiol USP Related Compound C (CAS 571-92-6)
- Estradiol Impurity 4 (CAS 566-75-6)
Recommended Standards
- 1,1-[(2-Ethyl-1,3-propanediyl)bis(oxymethylene)]bisbenzene (CAS 33498-90-7)
- 1,3-di-tert-butyl cyclohexane-1,3-dicarboxylate (CAS 220179-70-4)
- (S)-2-(1-((2-Amino-3,3-dimethylbutanamido)methyl)cyclohexyl)acetic acid (CAS 478185-94-3)
- 1,4,6-Androstatriene-17β-ol-3-one (CAS 4075-12-1)
- Difelikefalin Impurity 72 (CAS CATO-C4X-304172)
- Olopatadine Impurity 50 TFA salt (CAS CATO-C4X-171850)
- Rosuvastatin Impurity 201 (CAS CATO-C4X-1169201)
- (R)-3-(Methoxycarbonyl)-4-methylpentanoic acid (CAS 220498-08-8)
- 2-(5-Amino-3-(3-bromophenyl)-4-nitro-1H-pyrazol-1-yl)ethanol (CAS 1713476-62-0)
- 2-Ethoxy-N-(5-methylthiazol-2-yl)acetamide (CAS 1252144-19-6)
- 2-(Pyridin-3-ylmethyl)octahydropyrrolo[3,4-c]pyrrole (CAS 1422068-06-1)
- 2,4-Dimethylnicotinic Acid (CAS 55314-30-2)
- 3-(Cyanomethoxy)benzamide (CAS 500866-02-4)
- Semaglutide Impurity 146 (CAS 2645421-68-5)
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