Phloroglucinol Impurity 35 CAS 4018-65-9
| CAS No. | 4018-65-9 |
| Molecular Formula | C6H5ClO2 |
| Molecular Weight | 144.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Phloroglucinol Impurity 35.
As a process- or degradation-related impurity, Phloroglucinol Impurity 35 (CAS 4018-65-9, C6H5ClO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Phloroglucinol Impurity 35 (C6H5ClO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Phloroglucinol Impurity 35 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H5ClO2 |
| Molecular Weight | 144.56 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Related Phloroglucinol Standards
- Phloroglucinol impurity 45 (CAS 634-94-6)
- Phloroglucinol Impurity 59 (CAS 139173-32-3)
- Phloroglucinol Impurity 78 (CAS 18612-99-2)
- Phloroglucinol Impurity 28 (CAS 3934-97-2)
- Phloroglucinol Impurity 33 (CAS 824-46-4)
- Phloroglucinol Impurity 29 (CAS 2174-64-3)
- Phloroglucinol Impurity 31 (CAS 151-10-0)
- Phloroglucinol Impurity 28 (CAS 500-99-2)
Recommended Standards
- Minoxidil EP Impurity B (CAS 156-83-2)
- 4-Chlorocatechol (CAS 2138-22-9)
- Roflumilast impurity 22 (CAS 343927-62-8)
- 4-Chlororesorcinol (CAS 95-88-5)
- Ubrogepant Impurity 12 (CAS CATO-C4X-340212)
- Pregabalin Impurity 048 D-Tartrate (CAS 1094517-98-2)
- Osimertinib Impurity 22 (CAS CATO-C4X-204522)
- N-Isopropyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide (CAS 62347-24-4)
- 5-(2,6-Dichlorophenyl)oxazole (CAS 175211-71-9)
- 7-(4-(3-Hydroxynon-1-en-1-yl)-1-methyl-2-oxopyrrolidin-3-yl)heptanoic acid (CAS 62310-98-9)
- 5-Ethynyl-2-methoxy-4-methylpyridine (CAS 1186637-89-7)
- Diphenyl-7H-[1,2,4]triazolo[4,3-b][1,2,4]triazole-6-thiol (CAS 120187-11-3)
- 3-((2,4-Dichlorobenzyl)oxy)thieno[3,2-d]pyrimidin-4(3H)-one (CAS 339008-42-3)
- MLCK inhibitor peptide 18 (CAS 224579-74-2)
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