Tiotropium Bromide Monohydrate CAS 411207-31-3
| CAS No. | 411207-31-3 |
| Molecular Formula | C19H22NO4S2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Tiotropium Bromide Monohydrate (CAS 411207-31-3), molecular formula C19H22NO4S2BrH2O and molecular weight 490.43 g/mol, is a CATO reference standard with documented purity and traceability.
Tiotropium Bromide Monohydrate (C19H22NO4S2BrH2O) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H22NO4S2 Br H2O |
| Molecular Weight | 490.43 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Tiotropium Standards
- Tiotropium Impurity 26 (CAS 10299-90-8)
- Tiotropium Bromide Impurity 8 Potassium Salt (CAS 10304-09-3)
- Tiotropium Bromide EP Impurity H (Mixture of Enantiomers) (CAS 1044148-31-3)
- Tiotropium Bromide EP Impurity H-d3 Bromide (Mixture of Enantiomers) (CAS 1044148-31-3（unlabeled）)
- Tiotropium-d6 (CAS 1126775-44-7)
- Tiotropium-D3 Bromide (CAS 1127226-56-5)
- Tiotropium Bromide EP Impurity B (CAS 136310-64-0)
- Tiotropium EP Impurity D (CAS 136310-66-2)
Recommended Standards
- 5-(4-(Tert-butyl)phenyl)-4-(o-tolyl)-4h-1,2,4-triazole-3-thiol (CAS 328556-66-7)
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- Ethyl 4-cyano-3-hydroxy-5-methylsulfanylthiophene-2-carboxylate (CAS 203189-41-7)
- 2-Hydroxy-5-(2-(pyrrolidine-3-carbonyl)phenyl)isonicotinic acid (CAS 1261892-42-5)
- Ursodeoxycholic Acid Impurity 122 (CAS CATO-C4X-1422122)
- 3-(3-Ethoxyphenyl)isoxazol-5-amine (CAS 501902-17-6)
- 2-Cycloheptyl-1-phenylquinazolin-4(1H)-one (CAS 71608-84-9)
- 7-Methyl-3H-spiro[isobenzofuran-1,4'-piperidine] (CAS 777848-84-7)
- 2-Amino-2-(2,6-difluorophenyl)acetonitrile (CAS 926233-91-2)
- Liraglutide Impurity 10 TFA Salt (CAS CATO-C4X-199210)
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