Olopatadine Impurity 23 CAS 4174-83-8
| CAS No. | 4174-83-8 |
| Molecular Formula | C22H25NP |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Olopatadine Impurity 23 (C22H25NPHBrBr) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, organophosphorus functionality, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Olopatadine Impurity 23 (CAS 4174-83-8, C22H25NPHBrBr) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Olopatadine Impurity 23 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H25NP HBr Br |
| Molecular Weight | 495.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Olopatadine Standards
- Olopatadine Impurity 44 (CAS 111088-69-8)
- Olopatadine Impurity 43 (CAS 1127893-02-0)
- Olopatadine Methyl Ester HCl (CAS 113805-71-3（free base）)
- Olopatadine Impurity 51 (CAS 113806-01-2)
- Olopatadine Ethyl Ester (HCl) (CAS 113806-03-4)
- Olopatadine (CAS 113806-05-6)
- (E)-Olopatadine (CAS 113806-06-7)
- Olopatadine Impurity N3 (CAS 113835-76-0)
Recommended Standards
- Ceftizoxime Impurity 15 (CAS 54639-48-4)
- Pemafibrate Impurity 67 (CAS CATO-C4X-290367)
- Hydrocortisone Acetate EP Impurity F (CAS 1250-97-1)
- 3-Bromo-2-methylbenzofuran (CAS 58863-48-2)
- 6-Bromo-2-(trifluoromethyl)pyridin-3-amine (CAS 1805123-62-9)
- 1-(5-Chloro-2-methylphenyl)-4-((2,4,5-trichlorophenyl)sulfonyl)piperazine (CAS 496054-75-2)
- 2-(2-((3,5-Dimethoxybenzyl)thio)thiazol-4-yl)-N-propylacetamide (CAS 942001-71-0)
- 3-Aminodibenzofuran (CAS 4106-66-5)
- N-(thiophen-2-ylmethyl)-2,3-dihydro-1H-inden-2-amine hydrochloride (CAS 133276-00-3)
- Biotinyl-Neuropeptide Y (human, rat) trifluoroacetate salt (CAS 213779-13-6)
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